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Boc-Val-Cit-PAB

  Cat. No.:  DC33649   Featured
Chemical Structure
870487-09-5
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Field of application
Boc-Val-Cit-PAB is a linker for Antibody-Drug-Conjugation (ADC). The Val-Cit will specifically be cleaved by catepsin B. As this enzyme is only present in the lysosome the ADC payload will be release only in the cell. The Boc group can be deprotected under acidic conditions to generate a free amine group.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 870487-09-5
Chemical Name: Boc-Val-Cit-PAB
Synonyms: Boc-Val-Cit-PABA;Boc-Val-Cit-PAB;Boc-Val-Cit-PAB-OH;tert-butyl N-[(2S)-1-[[(2S)-5-(carbamoylamino)-1-[4-(hydroxymethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate;N-[(1,1-Dimethylethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide (ACI);AKOS030212115;AKOS030212115;AKOS030212115;AKOS030212115;AT10814;AT10814;AT10814;PD171228;AT10814;PD171228;BP-24174;PD171228;PD171228;BP-24174;N-[(1,1-Dimethylethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide;BP-24174;BP-24174;N-[(1,1-Dimethylethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide;SCHEMBL14012279;N-[(1,1-Dimethylethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide;N-[(1,1-Dimethylethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide;SCHEMBL14012279;WLZ3761;SCHEMBL14012279;SCHEMBL14012279;WLZ3761;MFCD22381208;WLZ3761;MFCD22381208;WLZ3761;BS-17687;BS-17687;EX-A3435;MFCD22381208;MFCD22381208;870487-09-5;BS-17687;EX-A3435;BS-17687;EX-A3435;870487-09-5;EX-A3435;TERT-BUTYL ((S)-1-(((S)-1-((4-(HYDROXYMETHYL)PHENYL)AMINO)-1-OXO-5-UREIDOPENTAN-2-YL)AMINO)-3-METHYL-1-OXOBUTAN-2-YL)CARBAMATE;870487-09-5;DB-086272;TERT-BUTYL ((S)-1-(((S)-1-((4-(HYDROXYMETHYL)PHENYL)AMINO)-1-OXO-5-UREIDOPENTAN-2-YL)AMINO)-3-METHYL-1-OXOBUTAN-2-YL)CARBAMATE;870487-09-5;TERT-BUTYL ((S)-1-(((S)-1-((4-(HYDROXYMETHYL)PHENYL)AMINO)-1-OXO-5-UREIDOPENTAN-2-YL)AMINO)-3-METHYL-1-OXOBUTAN-2-YL)CARBAMATE;DB-086272;TERT-BUTYL ((S)-1-(((S)-1-((4-(HYDROXYMETHYL)PHENYL)AMINO)-1-OXO-5-UREIDOPENTAN-2-YL)AMINO)-3-METHYL-1-OXOBUTAN-2-YL)CARBAMATE;DB-086272;DB-086272
SMILES: O(C(N[C@H](C(N[C@H](C(NC1C=CC(CO)=CC=1)=O)CCCNC(N)=O)=O)C(C)C)=O)C(C)(C)C
Formula: C23H37N5O6
M.Wt: 479.569785833359
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_15960_DC33649_870487-09-5
COA
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