D,L-Buthionine-(S,R)-sulfoximine |CAS 5072-26-4|DC Chemicals

Cas No.:	5072-26-4
Chemical Name:	Butanoic acid,2-amino-4-(S-butylsulfonimidoyl)-
Synonyms:	Butanoic acid,2-amino-4-(S-butylsulfonimidoyl)-;DL-Buthionine-[S,R]-Sulfoximine;2-amino-4-(butylsulfonimidoyl)butanoic acid;D,L-Buthionine-(S,R)-sulfoximine;DL -BUTHIONINE-S,R-SULFOXIMINE;DL-Buthionine (S,R)-sulfoximine;DL-Buthionine-(S,R)-sulfoximine
SMILES:	OC(C(N)CCS(CCCC)(=N)=O)=O
Formula:	C₈H₁₈N₂O₃S
M.Wt:	222.30512
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

In Vitro Buthionine sulfoximine is an analogs of methionine sulfoximine and inhibits gamma-glutamylcysteine synthetase about 20 times more effectively than prothionine sulfoximine and at least 100 times more effectively than methionine sulfoximine. In Vivo Treatment of mice bearing HT1080 and HT1080/DR4 xenografts with a continuous i.v infusion of nontoxic doses of D,L-Buthionine-(S,R)-sulfoximine (300 and 600 mg/kg/day) produce a 60% reduction of GSH plasma levels and greater than 95 % reduction in GSH tumor levels in both parental and multidrug-resistant tumors.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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