DC Chemicals' products qualify for U.S. tariff exemptions. We guarantee no price increases due to customs duties and maintain stable supply, continuing to deliver reliable research solutions to our American clients.
| Cas No.: | 374922-43-7 |
| Chemical Name: | 3-(Benzenesulfonyl)-1-(4-fluorophenyl)pyrrolo[3,2-b]quinoxalin-2-amine |
| Synonyms: | 3-(benzenesulfonyl)-1-(4-fluorophenyl)pyrrolo[3,2-b]quinoxalin-2-amine;AC1LZ7PQ;SureCN3483653;Oprea1_667095;STOCK2S-06230;MolPort-002-559-207;CAY10602;STL303186;1-(4-fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine;CAY 10602;C22H15FN4O2S;1-(4-Fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo(2,3-B)quinoxalin-2-amine;BDBM50193077;1105AH;s5918 |
| SMILES: | S(C1C([H])=C([H])C([H])=C([H])C=1[H])(C1=C(N([H])[H])N(C2C([H])=C([H])C(=C([H])C=2[H])F)C2C1=NC1=C([H])C([H])=C([H])C([H])=C1N=2)(=O)=O |
| Formula: | C22H15FN4O2S |
| M.Wt: | 418.4435 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | CAY10602 is a SIRT1 activator. |
| In Vitro: | Compounds (including CAY10602/compound 1) with SIRT1-activating properties have a significant effect on fat mobilization in differentiated adipocytes, and these compounds (including CAY10602) have antiobesity and/or antidiabetic properties. Compounds (including CAY10602) with SIRT1 activating potential exert strong suppression of TNF-α release at concentrations between 20 and 60 μM[1]. |
| Cell Assay: | 3T3L1 mouse fibroblasts and THP-1 leukemia cells are used and cultured following the supplier’s recommendations.THP-1 cells are treated first with representative compounds (including CAY10602/compound 1) followed by addition of lipopolysaccharide(LPS). THP-1 cells are plated at a density of 1.2×106 cells/mL in 0.4 mL (0.5×106 cells/treatment) in 24-well culture plates. The cells are preincubated with representative test compounds (including CAY10602) at 2 concentrations (20 or 60 μM) for 1 h under general tissue culture conditions[1]. |
| References: | [1]. Nayagam VM, et al. SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. J Biomol Screen. 2006 Dec;11(8):959-67. |
MSDS
COA
| LOT NO. | DOWNLOAD |
|
|
|
| 2018-0101 |
|
| 2018-0101 |
|