CAY 10602

Cas No.:	374922-43-7
Chemical Name:	3-(Benzenesulfonyl)-1-(4-fluorophenyl)pyrrolo[3,2-b]quinoxalin-2-amine
Synonyms:	3-(benzenesulfonyl)-1-(4-fluorophenyl)pyrrolo[3,2-b]quinoxalin-2-amine;AC1LZ7PQ;SureCN3483653;Oprea1_667095;STOCK2S-06230;MolPort-002-559-207;CAY10602;STL303186;1-(4-fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine;CAY 10602;C22H15FN4O2S;1-(4-Fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo(2,3-B)quinoxalin-2-amine;BDBM50193077;1105AH;s5918
SMILES:	S(C1C([H])=C([H])C([H])=C([H])C=1[H])(C1=C(N([H])[H])N(C2C([H])=C([H])C(=C([H])C=2[H])F)C2C1=NC1=C([H])C([H])=C([H])C([H])=C1N=2)(=O)=O
Formula:	C22H15FN4O2S
M.Wt:	418.4435
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	CAY10602 is a SIRT1 activator.
In Vitro:	Compounds (including CAY10602/compound 1) with SIRT1-activating properties have a significant effect on fat mobilization in differentiated adipocytes, and these compounds (including CAY10602) have antiobesity and/or antidiabetic properties. Compounds (including CAY10602) with SIRT1 activating potential exert strong suppression of TNF-α release at concentrations between 20 and 60 μM[1].
Cell Assay:	3T3L1 mouse fibroblasts and THP-1 leukemia cells are used and cultured following the supplier’s recommendations.THP-1 cells are treated first with representative compounds (including CAY10602/compound 1) followed by addition of lipopolysaccharide(LPS). THP-1 cells are plated at a density of 1.2×106 cells/mL in 0.4 mL (0.5×106 cells/treatment) in 24-well culture plates. The cells are preincubated with representative test compounds (including CAY10602) at 2 concentrations (20 or 60 μM) for 1 h under general tissue culture conditions[1].
References:	[1]. Nayagam VM, et al. SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. J Biomol Screen. 2006 Dec;11(8):959-67.