CCB 02|CCB02

Cas No.:	2100864-57-9
Chemical Name:	3-Methoxybenzo[b][1,6]naphthyridine-4-carbonitrile
Synonyms:	CCB02;CCB 02;3-Methoxybenzo[b][1,6]naphthyridine-4-carbonitrile
SMILES:	O(C([H])([H])[H])C1=C(C#N)C2C(C([H])=N1)=C([H])C1=C([H])C([H])=C([H])C([H])=C1N=2
Formula:	C₁₄H₉N₃O
M.Wt:	235.2408
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

CCB02 (CCB 02) is a specific small molecule inhibitor of CPAP-tubulin interaction with IC50 of 0.689 uM in AlphaScreen assay, selectively binds at the CPAP binding site of tubulin; does not inhibits a panel of cell cycle- and centrosome-related kinases; impairs proliferation of cells with centrosome amplification, activates extra centrosomes to nucleate enhanced numbers of microtubules prior to mitosis, causes cells to undergo centrosome de-clustering, prolonged multipolar mitosis, and cell death; demonstrates broad anti-invasive activity in various cancer models, including tyrosine kinase inhibitor (TKI)-resistant EGFR-mutant NSCLC.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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