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CM 10

  Cat. No.:  DC36895   Featured
Chemical Structure
692269-09-3
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More than 5000 active chemicals with high quality for research!
Field of application
CM 10 is an ALDH1A inhibitor that depletes CD133+ cancer stem cells.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 692269-09-3
Chemical Name: 2-(2-Propen-1-yl)-6-[[(1-propyl-1H-benzimidazol-2-yl)amino]methyl]phenol
Synonyms: CM 10; CM10; CM-10
SMILES: OC1=C(CNC2=NC3=CC=CC=C3N2CCC)C=CC=C1CC=C
Formula: C20H23N3O
M.Wt: 321.424
Purity: >98%
Sotrage: -20
Target: IC50: 1700 nM (ALDH1A1), 740 nM (ALDH1A2) and 640 nM (ALDH1A3)[1]
In Vitro: CM10 (12.5, 25, 50, 100 μM; 1 hour) inhibits ALDEFLUOR activity in live cells and preferentially depletes CD133+ ovarian cancer stem-like cells (CSCs)[1]. CM10 induces a cellular/nuclear swelling necroptotic phenotype[1].
References: [1]. Chefetz I, et al. A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. Cell Rep. 2019 Mar 12;26(11):3061-3075.e6. Chemical & Physical Properties Molecular Formula C20H23N3O Molecular Weight 321.42 Top
MSDS
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COA
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Cat. No. Product name Field of application
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DC74555 GYS32661 GYS32661 (GYS 32661) is a potent Rac inhibitor capable of inhibiting both Rac1 and Rac1b, inhibited activated Rac1 with IC50 of 1.18 uM in in vitro pull-down assays.
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