CNS-7056(CNS7056)|cas 308242-62-8|DC Chemicals|Price|Buy

Cas No.:	308242-62-8
Chemical Name:	methyl3-[(4S)-8-bromo-1-methyl-6-pyridin-2-yl-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propanoate
Synonyms:	CNS-7056,CNS7056,CNS 7056
SMILES:	O=C(OC)CC[C@H]1C2=NC=C(C)N2C3=CC=C(Br)C=C3C(C4=NC=CC=C4)=N1
Formula:	C₂₁H₁₉BrN₄O₂
M.Wt:	439.30516
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

For the detailed information of CNS-7056, the solubility of CNS-7056 in water, the solubility of CNS-7056 in DMSO, the solubility of CNS-7056 in PBS buffer, the animal experiment (test) of CNS-7056, the cell expriment (test) of CNS-7056, the in vivo, in vitro and clinical trial test of CNS-7056, the EC50, IC50,and Affinity of CNS-7056, Please contact DC Chemicals.

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2018-0101

Cat. No.	Product name	Field of application
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DC47638	CGP35348	CGP 35348 is a selective, brain penetrant, centrally active GABAB receptor antagonist with an EC50 of 34 μM. CGP 35348 shows affinity for the GABAB receptor only. CGP 35348 has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage.
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DC47033	Alogabat	Alogabat (example 8) is a GABAA α5 receptor positive allosteric modulators (PAMs) (extracted from patent WO2018104419A1).
DC46529	Tetrahydrodeoxycorticosterone	Tetrahydrodeoxycorticosterone, an neurosteroid, is a potent positive allosteric modulator (PAM) of GABAA receptor. Tetrahydrodeoxycorticosterone has potent neuroinhibitory properties.
DC46508	Anisatin	Anisatin, a pure toxic substance isolated from the seeds of a Japanese plant (Illicium anisatum) acts as a picrotoxin-like, non-competitive GABA antagonist. Anisatin suppresses GABA-induced currents in a concentration-dependent manner with an EC50 of ~1.10 μM.
DC46488	TACA	TACA (trans-4-Aminocrotonic acid) is a potent agonist of GABAA and GABAC receptors (KD= 0.6 μM). TACA also is GABA uptake inhibitor and substrate for GABA-T. TACA produces late biphasic responses in the MPG neurons.
DC46487	LU-32-176B	LU-32-176B, a GABA transporter 1(GAT1) selective inhibitor, is found to exert a synergistic anticonvulsant action with GAT2 transport inhibitor EF1502. LU-32-176B inhibits neurons, astrocytes and mGAT1 with the IC50 values of 2μM, 1μM, 4μM, respectively.
DC46367	Lesogaberan hydrochloride	Lesogaberan (hydrochloride) is a potent and selective GABAB receptor agonist with an EC50 of 8.6 nM for human recombinant GABAB receptors. Binding affinity (Kis) of 5.1 nM and 1.4 μM for rat brain GABAB and GABAA receptors, respectively.
DC46323	17β-Estradiol sulfate sodium	17β-Estradiol sulfate (sodium), also known as β-Estradiol 3-sulfate sodium salt, is a neuroactive steroid.