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CSRM617

  Cat. No.:  DC12576   Featured
Chemical Structure
787504-88-5
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More than 5000 active chemicals with high quality for research!
Field of application
CSRM617 (CSRM-617) is a small-molecule inhibitor of the transcription factor ONECUT2 (OC2) with Kd of 7.43 uM in SPR assays, binds to OC2-HOX domain directly.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 787504-88-5
Chemical Name: 2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzylidene)propanehydrazide
Synonyms: CSRM-617;CSRM 617
SMILES: C(N/N=C/C1=CC=C(O)C(O)=C1O)(=O)C(N)CO
Formula: C10H13N3O5
M.Wt: 255.23
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Rotinen M, et al. ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis. Nat Med. 2018 Dec;24(12):1887-1898.
Description: CSRM617 (CSRM-617) is a small-molecule inhibitor of the transcription factor ONECUT2 (OC2) with Kd of 7.43 uM in SPR assays, binds to OC2-HOX domain directly; inhibits cell growth and induced apoptosis in vitro in several PC cell lines that expressed moderate to high levels of OC2; significantly downregulates PEG10 protein levels in tumors from mice treated with CSRM617, suppresseses metastasis in 22Rv1 cells implanted subcutaneously nude mice.
In Vitro: CSRM617 (0.01-100 μM; 48 hours) inhibits cell growth in several PC cell lines: PC-3, 22RV1, LNCaP, C4-2 cells[1]. CSRM617 (10-20 μM; 48 hours) induces apoptosis in 22Rv1 cells results in cell death in a concentration-dependent fashion[1]. CSRM617 (20 μM; 72 hours) induces apoptosis in 22Rv1 cells by appearance of cleaved Caspase-3 and PARP[1].
References: [1]. Rotinen M, et al. ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis. Nat Med. 2018 Dec;24(12):1887-1898.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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