Cas No.: | 474-62-4 |
Chemical Name: | (24R)-5-Ergosten-3β-ol |
Synonyms: | (24R)-5-Ergosten-3β-ol |
SMILES: | C[C@@H](C(C)C)CC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CCC4CC(O)=CC[C@]4(C)[C@@]3([H])CC[C@]12C |
Formula: | C28H48O |
M.Wt: | 400.68 |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | Campesterol shows a weak cytotoxicity in non-proliferating human umbilical vein endothelial cells (HUVECs). Within the non-cytotoxic concentration range, campesterol significantly inhibits the bFGF-induced proliferation and tube formation of HUVECs in a concentration-dependent manner, while it does not affect the motility of HUVECs. 50 μg/mL of campesterol decreases the cell viability up to about 56% of control(IC50 of over 50 μg/mL).Campesterol effectively disrupts the bFGF-induced neovascularization in chick chorioallantoic membrane (CAM) in vivo. |