LTX-401

  Cat. No.:  DC10988   Featured
Chemical Structure
1398051-86-9
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Field of application
LTX-401 is a novel oncolytic amino acid derivative that specifically targets the Golgi apparatus, demonstrating significant potential in cancer therapy. In vitro studies reveal that LTX-401 effectively reduces the viability of various tumor cell lines, exhibiting cytotoxic activity across a range of concentrations. Notably, it shows the highest potency against the human malignant melanoma cell line MDA-MB-435S (IC50 = 13.5 μM) and the lowest activity against the human hepatocellular carcinoma cell line HEPG2 (IC50 = 35.4 μM). For other cell lines, the IC50 values fall within a narrow range of 19-32 μM. Importantly, LTX-401 does not induce hemolysis in red blood cells at concentrations effective for cancer cell death, with hemolytic activity only observed at much higher concentrations (400 μg/mL = 1087 μM). Additionally, LTX-401 demonstrates cytotoxicity against non-malignant cell lines, including HUV-EC-C endothelial cells, HaCat keratinocytes, and MRC-5 fibroblasts, suggesting a broad but selective mechanism of action.
Cas No.: 1398051-86-9
Chemical Name: N-(2-Aminoethyl)-α-(aminomethyl)-α-(3-phenylpropyl)benzenepentanamide Conjugate Acid (1:2)
Synonyms: N-(2-aminoethyl)-2-(aminomethyl)-5-phenyl-2-(3-phenylpropyl)pentanamide dihydrochloride;LTX-401 HCl
SMILES: Cl.Cl.O=C(C(CN)(CCCC1C=CC=CC=1)CCCC1C=CC=CC=1)NCCN
Formula: C23H35Cl2N3O
M.Wt: 440.449504137039
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: LTX-401 (LTX401) is an oncolytic amino acid derivative with potential immunogenic properties, selectively destroys the structure of the Golgi apparatus; selectively enriched in the Golgi rather than in mitochondria or in the cytosol, induced all major hallmarks of immunogenic cell death detectable with biosensor cell lines including calreticulin exposure, ATP release, HMGB1 exodus and a type-1 interferon response; induces DAMP release in melanoma cells and causes complete regression of B16 melanoma.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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