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Desmethyl dabrafenib

  Cat. No.:  DC11055   Featured
Chemical Structure
1195765-47-9
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Field of application
Desmethyl dabrafenib (GSK2167542, Dabrafenib metabolite M8) is the desmethyl- metabolic byproduct of Dabrafenib, ameliorates developmental pathologies of Kabuki Syndrome in vivo..
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1195765-47-9
Chemical Name: N-[3-[5-(2-aminopyrimidin-4-yl)-2-propan-2-yl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
Synonyms: GSK2167542,GSK-2167542,GSK 2167542
SMILES: C(S(NC1=CC=CC(C2=C(C3C=CN=C(N)N=3)SC(C(C)C)=N2)=C1F)(=O)=O)1=C(F)C=CC=C1F
Formula: C22H18F3N5O2S2
M.Wt: 505.534
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: 1. Bershas DA, et al. Drug Metab Dispos. 2013 Dec;41(12):2215-24. 2. Ouellet D, et al. J Clin Pharmacol. 2014 Jun;54(6):696-706. 3. Suttle AB, et al. J Clin Pharmacol. 2015 Apr;55(4):392-400. 4. Tsai IC, et al. Sci Rep. 2018 Jul 17;8(1):10779.
Description: Desmethyl dabrafenib (GSK2167542, Dabrafenib metabolite M8) is the desmethyl- metabolic byproduct of Dabrafenib, ameliorates developmental pathologies of Kabuki Syndrome in vivo.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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