BYK191023 dihydrochloride|BYK-191023

Cas No.:	1216722-25-6
Chemical Name:	2-[2-(4-Methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine dihydrochloride
Synonyms:	BYK-191023
SMILES:	C12NC(CCC3=NC=CC(OC)=C3)=NC1=CC=CN=2.[H]Cl.[H]Cl
Formula:	C₁₄H₁₆Cl₂N₄O
M.Wt:	327.209
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

BYK191023 dihydrochloride (BYK-191023) is a potent, highly selective inhibitor of inducible nitric-oxide synthase (iNOS) with IC50 of 86 nM, >20-fold selectivity over nNOS and eNOS (IC50=17 and 162 uM); exhibits an affinity for iNOS, nNOS, and eNOS of 450 nM, 30 uM, and >500 uM, respectively; inhibits cellular nitrate/nitrite synthesis in RAW, rat mesangium, and human embryonic kidney 293 cells with IC50 values 40- to 100-fold higher than at the isolated enzyme; dose-dependently suppresses the LPS-induced increase in plasma nitrate/nitrite (NO(x)) levels with ED50 of 14.9 micromol/kg/h, partially restores normal blood pressure responses to norepinephrine and sodium nitroprusside in model of LPS-induced vascular hyporesponsiveness.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC47543	FeTPPS	FeTPPS, a 5,10,15,20-tetrakis (4-sulfonatophenyl) porphyrin iron III chloride peroxynitrite decomposition catalyst, possessed evident neuroprotective effects in a experimental model of spinal cord damage. FeTPPS acts as a peroxynitrite scavenger and anti-nitrating agent in vivo. FeTPPS reduces nitric oxide (NO) production and apoptosis process.
DC47240	Carboxy-PTIO	Carboxy-PTIO is a potent nitric oxide (NO) scavenger that can make a quick reaction with NO to produce NO2. Carboxy-PTIO can prevent hypotension and endotoxic shock through the direct scavenging action against NO in lipopolysaccharide-stimulated rat model.
DC46445	Kazinol B	Kazinol B, a prenylated flavan with a dimethyl pyrane ring, is an inhibitor of nitric oxide (NO) production. Kazinol B improves insulin sensitivity by enhancing glucose uptake via the insulin-Akt signaling pathway and AMPK activation. Kazinol B has the potential for diabetes mellitus research.
DC46347	Carboxyebselen	Carboxyebselen (HOOC-Ebs) is a potent and selective inhibitor of endothelial nitric oxide synthase (eNOS).
DC45976	Valeriandoid F	Valeriandoid F is an iridoid, which potently inhibits NO production with an IC50 value of 0.88 μM. Valeriandoid F has anti-inflammatory and antiproliferative activities.
DC45854	Regaloside A	Regaloside A, a phenylpropanoid, shows significant DPPH radical scavenging activity of 58.0% at 160 ppm. Regaloside A has anti-inflammatory activity.
DC45575	Amaroswerin	Amaroswerin is a bioactive secoiridoid glucoside from Swertia mussotii. Amaroswerin has anti-inflammatory, antidiabetic, antiviral, anticholinergic and immunomodulatory activities. Amaroswerin inhibits NO release with an IC50 value of 5.42 μg/mL in RAW264.7 cells.
DC45429	3-O-Acetyl-16α-hydroxydehydrotrametenolic acid	3-O-Acetyl-16α-hydroxydehydrotrametenolic acid, an anti-inflammatory triterpenoid, inhibits NO production and iNOS expression in LPS-stimulated Raw264.7 cells.
DC44974	Physalin L	Physalin L inhibits LPS-induced NO production in macrophages with the average inhibitory rate of 70.97%. Anti-inflammatory activity.
DC44973	Isomaculosidine	Isomaculosidine is an alkaloid that can be isolated from D. dasycarpus. Isomaculosidine can inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 microglial cells.