MK-8318|MK8318

Cas No.:	1416581-40-2
Chemical Name:	4-(cyclopropyl((3aS,9R,9aR)-7-fluoro-4-(4-(trifluoromethoxy)benzoyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]quinolin-9-yl)amino)-4-oxobutanoic acid
Synonyms:	MK8318
SMILES:	C(O)(=O)CCC(N(C1CC1)[C@@H]1C2=C(N(C(=O)C3=CC=C(OC(F)(F)F)C=C3)[C@@]([H])3CCC[C@@]31[H])C=CC(F)=C2)=O
Formula:	C₂₇H₂₆F₄N₂O₅
M.Wt:	534.508
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

MK-8318 (MK8318) is a potent, selective, orally available CRTh2 receptor antagonist with Ki of 5 nM, shows nM potency in functional assay (cAMP IC50=8 nM, β-Arrestin IC50=3.5 nM; blocks late airway response (LAR) and airway hyperresponsiveness (AHR) after i.v. infusion at 1 mpk, also displays good efficacy on BAL cells/pulmonary function from ovalbumin sensitized and challenged Brown Norway rats at 3, 10, and 30 mpk oral dosing; MK-8318 exhibits a favorable PK profile suitable for once daily oral dosing for potential treatment of asthma.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC42503	Taprenepag isopropyl	Taprenepag isopropyl is a highly selective EP2 receptor agonist.
DC47374	Aligeron	Aligeron is a non-selective prostaglandin (PG) antagonist, and has vasodilatory properties.
DC47373	CAY10580	CAY10580 is a potent and selective prostaglandin EP4 receptor agonist (Ki=35 nM).
DC47183	Aganepag isopropyl	Aganepag isopropyl (AGN-210961) is an EP2 agonist.
DC47172	15-Keto latanoprost	15-Keto latanoprost is a metabolite of Latanoprost, which is an ocular hypotensive agent.
DC47127	Pexopiprant	Pexopiprant is an oral antagonist of the prostaglandin D2 receptor 2 (DP2),Ki ＜ 100nM. Pexopiprant can be used in studies of asthma.
DC47089	Treprostinil palmitil	Treprostinil palmitil (TP) is the prodrug of DP1 and EP2 agonist, Treprostinil (UT-15), whose EC50 values were 0.6 and 6.2 nM, respectively. Treprostinil palmitil is a pure prodrug and possesses no inherent binding to G-protein coupled receptors including prostanoid receptors.
DC46853	BGC-20-1531 free base	BGC-20-1531 (PGN 1531) free base is a potent and selective prostanoid EP4 receptor antagonist, with a pKb of 7.6. BGC-20-1531 free base has the potential for the research of migraine headache.
DC46564	Bimatoprost D5	Bimatoprost D5 (AGN 192024 D5) is a deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog and is a topical hypotensive agent frequently used for treating ocular hypertension and glaucoma. Bimatoprost also has an antiadipogenic effect.
DC45799	TCS 2510	TCS 2510 is a selective EP4 agonist. TCS 2510 can be used for the research of metabolic diseases.