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OTS193320

  Cat. No.:  DC11256   Featured
Chemical Structure
2093401-33-1
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More than 5000 active chemicals with high quality for research!
Field of application
OTS193320 (OTS-193320) is a potent inhibitor of protein methyltransferase SUV39H2 with IC50 of 22.2 nM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2093401-33-1
Chemical Name: (1s,4s)-N1-(2-(5-chloro-2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-7-yl)-N4-(4-nitrobenzyl)cyclohexane-1,4-diamine
Synonyms: OTS-193320;OTS 193320
SMILES: [C@@H](NC1C=CN2C=C(C3=CC(Cl)=C(OC)C=C3OC)N=C2C=1)1CC[C@@H](NCC2=CC=C([N+]([O-])=O)C=C2)CC1
Formula: C28H30ClN5O4
M.Wt: 536.029
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: 1. Vougiouklakis T, et al. Oncotarget. 2018 Aug 7;9(61):31820-31831. View Related Products by Target Histone Methyltransferase (HMTase)
Description: OTS193320 (OTS-193320) is a potent inhibitor of protein methyltransferase SUV39H2 with IC50 of 22.2 nM; significantly reduces global H3K9 tri-methylation (H3K9me3) in breast cancer cells in vitro and induces apoptotic cell death, attenuates γ-H2AX levels in combination with doxorubicin compared with the DOX treatment alone, and causes a significant reduction in breast cancer cell viability when compared to the treatment with a single agent; causes growth suppressive effect of SUV39H2-positive A549 lung cancer cells with IC50 of 0.38 uM.
Target: SUV39H2
References: 1. Vougiouklakis T, et al. Oncotarget. 2018 Aug 7;9(61):31820-31831. View Related Products by Target Histone Methyltransferase (HMTase)
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
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