NTCP binder peptide WL4|

Cas No.:
Chemical Name:	(3S,6S,9S,12S,15S,18R,24S,27S,30S,33S,36S,39S,44aS)-6-((1H-imidazol-4-yl)methyl)-33,39-bis((1H-indol-3-yl)methyl)-3-(2-amino-2-oxoethyl)-N-((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)-9-benzyl-30,36-di((S)-sec-butyl)-12,15,24-tris(4-hydroxybenzyl)-27-isopr
SMILES:	C1CC(=O)N[C@H](CC2=CC=C(O)C=C2)C(=O)N[C@H](C(C)C)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H](CC2C3=C(NC=2)C=CC=C3)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H](CC2C3=C(NC=2)C=CC=C3)C(=O)N2CCC[C@@]2([H])S(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CC2=CNC=N2)C(=O)N[C@H](CC2=CC=CC=C2)C(=O)
Formula:	C₉₉H₁₂₂N₂₀O₂₀S
M.Wt:	1944.245
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

NTCP binder peptide WL4 is a macrocyclic peptide, pan-genotypic inhibitor of HBV cellular entry via targeting the cell-surface receptor for HBV, sodium taurocholate cotransporting polypeptide (NTCP, Kd=42 nM), reduces HBs antigen levels in culture supernatants with IC50 of 0.66 uM; also inhibits cellular entry by the related hepatitis D virus (HDV), and is active against diverse strains of HBV (including clinically relevant nucleos(t)ide analog-resistant and vaccine escaping strains); exhibitsno inhibition of NTCP-mediated bile acid uptake in contrast to other NTCP-binding HBV entry inhibitors.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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