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E3 Ligand-Linker Conjugate 9

  Cat. No.:  DC11575   Featured
Chemical Structure
1957236-20-2
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More than 5000 active chemicals with high quality for research!
Field of application
An E3 ligase ligand-linker conjugate for PROTAC.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1957236-20-2
Chemical Name: E3 Ligase Ligand-Linker Conjugates 21
SMILES: NCCOCCOCCOCCNC(COC1=C(C2=CC=C1)C(N(C(CCC3=O)C(N3)=O)C2=O)=O)=O
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: E3 Ligase Ligand-Linker Conjugates 21 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.
In Vitro: E3 Ligase Ligand-Linker Conjugates 21 is composed of Degron (E3 ubiquitin ligase) and a linker, and they are used in PROTAC technology. E3 Ligase Ligand-Linker Conjugates 21 binds to the targeting ligand to induce the target protein (including BRD4, BRD2, and BRD3) degradation[1].
References: [1]. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017007612 A1
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
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DC50069 (S,R,S)-AHPC-PEG4-NH2(E3 ligase Ligand-Linker Conjugates 7) (S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
DC50068 (S,R,S)-AHPC-Me-C10-NH2 (S,R,S)-AHPC-Me-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432
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