| DC41105 |
Prexasertib dimesylate
|
Prexasertib dimesylate (LY2606368 dimesylate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. Prexasertib dimesylate inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). Prexasertib dimesylate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib dimesylate shows potent anti-tumor activity. |
| DC41104 |
Prexasertib Mesylate Hydrate
|
Prexasertib Mesylate Hydrate (LY2606368 Mesylate Hydrate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. Prexasertib Mesylate Hydrate inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). Prexasertib Mesylate Hydrate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib Mesylate Hydrate shows potent anti-tumor activity. |
| DC40569 |
Chk1-IN-5
|
Chk1-IN-5 is a potent checkpoint kinase 1 (Chk1) inhibitor. Chk1-IN-5 inhibits Chk1 phosphorylation and inhibits tumor growth in colon cancer xenograft model. |
| DC11732 |
GNE-900
|
GNE-900 (GNE900) is a potent, selective, ATP-competitive, and orally bioavailable Chk1 inhibitor with IC50 of <1 nM. |
| DC9399 |
CCT241533 (hydrochloride)
|
CCT241533 Hcl is a potent serine/threonine checkpoint kinase (Chk2) inhibitor with IC50 of 3 nM; shows minimal cross-reactivity against a panel of kinases at 1 uM.
|
| DC11713 |
NSC-109555 ditosylate
|
A potent, selective, reversible, ATP-competitive Chk2 inhibitor with IC50 of 0.2 uM. |
| DC11733 |
SAR-020106
|
A potent, selective, ATP-competitive Chk1 inhibitor with IC50 of 13.3 nM. |
| DC11711 |
VER-158411
|
A potent, selective, ATP-competitive Chk1 and Chk2 inhibitor with IC50 of 4.4 nM and 4.5 nM, respectively. |
| DC11717 |
PD-321852
|
A potent, reasonably selective Chk1 inhibitor with cell IC50 of 5 nM. |
| DC11714 |
PV-1019
|
A potent, ATP-competitive and highly selective Chk2 inhibitor with IC50 of 138 nM. |
