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PV-1115

  Cat. No.:  DC11715  
Chemical Structure
1093793-10-2
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More than 5000 active chemicals with high quality for research!
Field of application
A potent and highly selective Chk2 inhibitor with IC50 of 0.14 nM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1093793-10-2
Chemical Name: N-(4-(1-(2-(4,5-dihydro-1H-imidazol-2-yl)hydrazono)ethyl)phenyl)-7-nitro-1H-indole-2-carboxamide
Synonyms: PV 1115;PV1115
SMILES: N1C2=C(C=CC=C2[N+]([O-])=O)C=C1C(NC1=CC=C(/C(=N/NC2NCCN=2)/C)C=C1)=O
Formula: C20H19N7O3
M.Wt: 405.418
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A potent and highly selective Chk2 inhibitor with IC50 of 0.14 nM; displays greater than 100 uM for Chk1 in vitro.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC41105 Prexasertib dimesylate Prexasertib dimesylate (LY2606368 dimesylate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. Prexasertib dimesylate inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). Prexasertib dimesylate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib dimesylate shows potent anti-tumor activity.
DC41104 Prexasertib Mesylate Hydrate Prexasertib Mesylate Hydrate (LY2606368 Mesylate Hydrate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. Prexasertib Mesylate Hydrate inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). Prexasertib Mesylate Hydrate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib Mesylate Hydrate shows potent anti-tumor activity.
DC40569 Chk1-IN-5 Chk1-IN-5 is a potent checkpoint kinase 1 (Chk1) inhibitor. Chk1-IN-5 inhibits Chk1 phosphorylation and inhibits tumor growth in colon cancer xenograft model.
DC11732 GNE-900 GNE-900 (GNE900) is a potent, selective, ATP-competitive, and orally bioavailable Chk1 inhibitor with IC50 of <1 nM.
DC9399 CCT241533 (hydrochloride) CCT241533 Hcl is a potent serine/threonine checkpoint kinase (Chk2) inhibitor with IC50 of 3 nM; shows minimal cross-reactivity against a panel of kinases at 1 uM.
DC11713 NSC-109555 ditosylate A potent, selective, reversible, ATP-competitive Chk2 inhibitor with IC50 of 0.2 uM.
DC11733 SAR-020106 A potent, selective, ATP-competitive Chk1 inhibitor with IC50 of 13.3 nM.
DC11711 VER-158411 A potent, selective, ATP-competitive Chk1 and Chk2 inhibitor with IC50 of 4.4 nM and 4.5 nM, respectively.
DC11717 PD-321852 A potent, reasonably selective Chk1 inhibitor with cell IC50 of 5 nM.
DC11714 PV-1019 A potent, ATP-competitive and highly selective Chk2 inhibitor with IC50 of 138 nM.
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