GB-88|GB 88;GB88

Cas No.:	1416435-96-5
Chemical Name:	N-((S)-3-cyclohexyl-1-(((2S,3S)-3-methyl-1-oxo-1-(spiro[indene-1,4'-piperidin]-1'-yl)pentan-2-yl)amino)-1-oxopropan-2-yl)isoxazole-5-carboxamide
Synonyms:	GB 88;GB88
SMILES:	O1C(C(N[C@H](CC2CCCCC2)C(N[C@H]([C@H](C)CC)C(=O)N2CCC(CC2)2C3=C(C=CC=C3)C=C2)=O)=O)=CC=N1
Formula:	C₃₂H₄₂N₄O₄
M.Wt:	546.712
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

GB-88 is a selective, orally available PAR2 antagonist that inhibits PAR2 activated Ca(2+) release with IC50 of 2 uM; At 10 mg/kg, inhibits acute colonic inflammation induced in rats by the PAR2 agonist SLIGRL-NH2 with markedly reduced edema, mucin depletion, PAR2 receptor internalization, and mastocytosis.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC47359	SCH79797	SCH79797 is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 inhibits thrombin-induced platelet aggregation with an IC50 of 3 μM. SCH79797 has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes.
DC47251	FR-171113	FR171113 is a specific and non-peptide thrombin receptor antagonist. FR171113 exhibits the antithrombotic effects of a PAR1 antagonist. FR171113 inhibits thrombin-induced platelet aggregation with an IC50 of 0.29 μM..
DC46522	Parstatin(mouse) TFA	Parstatin(mouse) TFA, a cell-penetrating PAR-1 thrombin receptor agonist peptide, is a potent inhibitor of angiogenesis.
DC46521	Parstatin(human) TFA	Parstatin(human) TFA, a cell-penetrating PAR-1 thrombin receptor agonist peptide, is a potent inhibitor of angiogenesis.
DC45574	Protease-Activated Receptor-1, PAR-1 Agonist TFA	Protease-Activated Receptor-1, PAR-1 Agonist TFA is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist TFA corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor.
DC45261	Parstatin(human)	Parstatin(human), a cell-penetrating PAR-1 thrombin receptor agonist peptide, is a potent inhibitor of angiogenesis.
DC45260	Parstatin(mouse)	Parstatin(mouse), a cell-penetrating PAR-1 thrombin receptor agonist peptide, is a potent inhibitor of angiogenesis.
DC45259	Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA	Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA is a proteinase-activated receptor (PAR-3) agonist peptide.
DC42021	Protease-Activated Receptor-3 (PAR-3) (1-6), human	Protease-Activated Receptor-3 (PAR-3) (1-6), human is a proteinase-activated receptor (PAR-3) agonist peptide.
DC42020	Protease-Activated Receptor-1, PAR-1 Agonist	Protease-Activated Receptor-1, PAR-1 Agonist is a thrombin-specific, protease-activated receptor 1 (PAR-1)-specific agonist peptide.