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| Cas No.: | 656222-54-7 |
| Chemical Name: | 2-(2-cyanoacetyl)-N-(3,4-dichlorophenyl)hydrazine-1-carbothioamide |
| Synonyms: | iKIX 1;iKIX-1 |
| SMILES: | O=C(NNC(NC1=CC=C(Cl)C(Cl)=C1)=S)CC#N |
| Formula: | C10H8Cl2N4Os |
| M.Wt: | 303.17 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | A small-molecule inhibitor of the interaction of the C. glabrata Pdr1 activation domain with the C. glabrata Gal11A KIX domain with Ki of 18 uM; blocks Gal11/Med15 recruitment and inhibits Pdr1-dependent gene activation and re-sensitizes drug-resistant C. glabrata to azole antifungals in vitro and in animal models for disseminated and urinary tract C. glabrata infection; a novel therapeutic strategy in fungal infectious disease. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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