ABD328|ABD-328;ABD 328

Cas No.:	1055896-19-9
Chemical Name:	1-(2',4'-dichloro-[1,1'-biphenyl]-4-yl)-6-hydroxyhexan-1-one
Synonyms:	ABD-328;ABD 328
SMILES:	C(C1=CC=C(C2=CC=C(Cl)C=C2Cl)C=C1)(=O)CCCCCO
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

ABD328 (ABD-328) is an orally active, small molecule inhibitor of RANKL and TNF signalling that inhibits inflammation in vivo; inhibits TNF-induced activation of the NF-κB pathway, ERK, JNK and MAPKs in osteoclasts and macrophages, suppresses inflammatory arthritis, inhibits joint destruction and prevented systemic bone loss in mice model of rheumatoid arthritis.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC47551	IMD-vanillin	IMD-vanillin is a novel imidazoquinolinone-NF-κB immunomodulator dimers.
DC47550	HE 3286	HE3286, a synthetic derivative of the adrenal steroid β-AET, is an orally-active partially NF-κB inhibitor.
DC47549	IMD-biphenylA	IMD-biphenylA is a novel imidazoquinolinone-NF-κB immunomodulator dimer that improves the adjuvanticity of small molecule immune potentiators.
DC47548	IMD-ferulic	IMD-ferulic is a covalently linked NF-κB modulator that improves the adjuvanticity of small molecule immune potentiators.
DC47547	Lucyoside B	Lucyoside B inhibits the production of inflammatory mediators via both NF-κB and activator protein-1 pathways in activated macrophages.
DC47546	Rubioncolin C	Rubioncolin C exerts anti-tumor activity by inducing apoptotic and autophagic Cell Death and inhibiting the NF-κB and Akt/mTOR/P70S6K Pathway in Human Cancer Cells.
DC47545	IMD-biphenylC	IMD-biphenylC is a novel imidazoquinolinone-NF-κB immunomodulator dimer that inhibits tumor proliferation while induces low systemic inflammation and reduces adjuvant toxicity.
DC47544	IMD-catechol	IMD-catechol is a novel imidazoquinolinone-NF-κB immunomodulator dimer that improves efficacy in a CT26 mouse colon carcinoma tumor model while eliciting minimal adjuvant toxicity.
DC46510	Sulfuretin	Sulfuretin inhibits the inflammatory response by suppressing the NF-κB pathway. Sulfuretin can be used for the research of allergic airway inflammation. Sulfuretin reduces oxidative stress, platelet aggregation, and mutagenesis. Sulfuretin is a competitive and potent inhibitor of monophenolase and diphenolase activities with the IC50 of 13.64 μM.
DC46210	PTD-p65-P1 Peptide	PTD-p65-P1 Peptide is a nuclear transcription factor NF-kappaB inhibitor, composed of a membrane-translocating peptide sequence generated from antennapedia (PTD) conjugated with p65-P1, which selectively inhibits activation induced by various inflammatory stimuli.