(+)-Kavain

  Cat. No.:  DC20149   Featured
Chemical Structure
500-64-1
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More than 5000 active chemicals with high quality for research!
Field of application
(+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. (+)-Kavain is shown to bind at the α4β2δ GABA
Cas No.: 500-64-1
Chemical Name: (+)-Kavain
Synonyms: Kavain;Kawain;2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-styryl-, (+)-;2H-Pyran-2-one,5,6-dihydro-4-methoxy-6-[(1E)-2-phenylethenyl]-, (6R)-;5,6-Dihydro-4-methoxy-6-styryl-2H-pyran-2-one;5,6-Dihydro-4-methoxy-6-styryl-2-pyron;gonosan;L-KAWAIN;(+)-Kavain;Kavain, dl-;Kawaih;W1ES06373M;(R)-Kawain;(R)-5,6-Dihydro-4-methoxy-6-styryl-2H-pyran-2-one;4-Methoxy-6-(beta-phenylvinyl)-5,6-dihydro-alpha-pyrone;5-Hydroxy-3-methoxy-7-phenyl-2,6-heptadienoic acid gamma-lactone;2H-PYRAN-2-ONE, 5,6-DIHYDRO-4-METHOXY-6-STYRYL-, (R)-;Kavaform (TN);Prestwick3_000207;Prestwick2_000207;(R
SMILES: O1C(C([H])=C(C([H])([H])[C@]1([H])/C(/[H])=C(\[H])/C1C([H])=C([H])C([H])=C([H])C=1[H])OC([H])([H])[H])=O
Formula: C14H14O3
M.Wt: 230.2592
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: In Vitro (+)-Kavain (10-300 μM) enhances GABA-elicited responses in a concentration-dependent manner. The modulatory effect of Kavain is moderate, with only 170±23% of enhancement measured at 300 μM[2]. (+)-Kavain inhibits TNF-α secretion in cells via suppression of LITAF.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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