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Dafadine A

  Cat. No.:  DC20353   Featured
Chemical Structure
1065506-69-5
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More than 5000 active chemicals with high quality for research!
Field of application
​​Dafadine-A​​ represents a novel class of cytochrome P450 inhibitors with unique species-specific activity.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1065506-69-5
Chemical Name: Dafadine-A
Synonyms: Dafadine-A;Dafadine A;4-[1-({ 5-[(2,6-Dimethylphenoxy)methyl]-3-isoxazolyl}carbonyl)-4-piperidinyl]pyridine;[5-[(2,6-Dimethylphenoxy)methyl]-3-isoxazolyl][4-(4-pyridinyl)-1-piperidinyl]methanone;Q27160185;{5-[(2,6-dimethylphenoxy)methyl]-1,2-oxazol-3-yl}[4-(pyridin-4-yl)piperidin-1-yl]methanone;EX-A4970;(5-((2,6-dimethylphenoxy)methyl)isoxazol-3-yl)(4-(pyridin-4-yl)piperidin-1-yl)methanone;AC-36585;4-[1-({5-[(2,6-dimethylphenoxy)methyl]-3-isoxazolyl}carbonyl)-4-piperidinyl]-pyridine;Dafadine A?;4-(1-{5-[(2,6-dimethylphenoxy)methyl]-1,2-oxazole-3-carbonyl}piperidin-4-yl)pyridine;[5-[(2,6-dimethylphenoxy) methyl]-1,2-oxazol-3-yl]-(4-pyridin-4-ylpiperidin-1-yl)methanone;AKOS000365820;F85040;CHEBI:88327;AS-16383;GLXC-02932;HMS2928H15;1065506-69-5;[5-[(2,6-dimethylphenoxy)methyl]-1,2-oxazol-3-yl]-(4-pyridin-4-ylpiperidin-1-yl)methanone;DA-72538;NCGC00402231-02;CHEMBL1585869;CS-3184;SMR000654704;MLS001090772;HY-16670
SMILES: O=C(N1CCC(C2=CC=NC=C2)CC1)C3=NOC(COC4=C(C)C=CC=C4C)=C3
Formula: C23H25N3O3
M.Wt: 391.46290564537
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Dafadine-A, an analog of dafadine, is a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans; also inhibits the mammalian ortholog of DAF-9(CYP27A1).The DAF-9 cytochrome P450 is a key regulator of dauer formation, developmental timing and longevity in the nematodeCaenorhabditis elegans. Here we describe the first identified chemical inhibitor of DAF-9 and the first reported small-molecule tool that robustly induces dauer formation in typical culture conditions. This molecule (called dafadine) also inhibits the mammalian ortholog of DAF-9(CYP27A1), suggesting that dafadine can be used to interrogate developmental control and longevity in other animals.
Target: DAF-9(CYP27A1) inhibitor
References: [1]. Luciani GM, et al. Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans. Nat Chem Biol. 2011 Nov 6;7(12):891-3
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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