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Dafadine A

  Cat. No.:  DC20353   Featured
Chemical Structure
1065506-69-5
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More than 5000 active chemicals with high quality for research!
Field of application
Dafadine A is the first reported small-molecule DAF-9 cytochrome P450 inhibitor that robustly induces dauer formation in in the nematode Caenorhabditis elegans.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1065506-69-5
Chemical Name: Dafadine-A
Synonyms: Dafadine-A;Dafadine A;4-[1-({ 5-[(2,6-Dimethylphenoxy)methyl]-3-isoxazolyl}carbonyl)-4-piperidinyl]pyridine;[5-[(2,6-Dimethylphenoxy)methyl]-3-isoxazolyl][4-(4-pyridinyl)-1-piperidinyl]methanone
SMILES: N1=CC=C(C=C1)C2CCN(CC2)C(=O)C3C=C(COC4=C(C)C=CC=C4C)ON=3
Formula: C23H25N3O3
M.Wt: 391.46290564537
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Dafadine-A, an analog of dafadine, is a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans; also inhibits the mammalian ortholog of DAF-9(CYP27A1).The DAF-9 cytochrome P450 is a key regulator of dauer formation, developmental timing and longevity in the nematodeCaenorhabditis elegans. Here we describe the first identified chemical inhibitor of DAF-9 and the first reported small-molecule tool that robustly induces dauer formation in typical culture conditions. This molecule (called dafadine) also inhibits the mammalian ortholog of DAF-9(CYP27A1), suggesting that dafadine can be used to interrogate developmental control and longevity in other animals.
Target: DAF-9(CYP27A1) inhibitor
References: [1]. Luciani GM, et al. Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans. Nat Chem Biol. 2011 Nov 6;7(12):891-3
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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