ANT431|ANT 431;ANT-431

Cas No.:	1639972-90-9
Chemical Name:	5-(Pyridin-3-ylsulfonylamino)-1,3-thiazole-4-carboxylic acid
Synonyms:	ANT431;5-(pyridin-3-ylsulfonylamino)-1,3-thiazole-4-carboxylic acid;5-(Pyridine-3-sulfonamido)thiazole-4-carboxylic acid;5-(pyridine-3-sulfonamido)-1,3-thiazole-4-carboxylic acid;G1N
SMILES:	S(C1C=NC=CC=1)(NC1=C(C(=O)O)N=CS1)(=O)=O
Formula:	C₉H₇N₃O₄S₂
M.Wt:	285.299578905106
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

ANT431 is a novel potent metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2, shows a comparatively weak inhibitor of VIM-1 and IMP-1 (Ki of 14.6 and 4.15 uM, respectively); potentiate the activity of meropenem (MEM) against a broad range of MBL-producing carbapenem-resistant Enterobacteriaceae (CRE), restore its efficacy against an Escherichia coli NDM-1 strain in a murine thigh infection model.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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