AZD 5991|AZD5991

Cas No.:	2143061-81-6
Chemical Name:	AZD5991
Synonyms:	AZD5991;E3T5XXY9HX;A16880;E4W;17-Chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentazaheptacyclo[27.7.1.14,7.011,15.016,21.020,24.030,35]octatriaconta-1(36),4(38),6,11,14,16,18,20,23,29(37),30,32,34-tridecaene-23-carboxylic acid;US10196404, Example 1;US10196404, Example 2;US10196404, Example 3;BDBM333146;BCP23513;BCP30972;BCP30973;NSC807055;s8643;D;Unii-E3T5xxy9HX;AZD-5991
SMILES:	ClC1C([H])=C([H])C2C3C([H])([H])C([H])([H])C([H])([H])OC4=C([H])C(=C([H])C5=C([H])C([H])=C([H])C([H])=C45)SC([H])([H])C4=C([H])C(C([H])([H])SC([H])([H])C5C(=C(C([H])([H])[H])N(C([H])([H])[H])N=5)C=1C=2N(C([H])([H])[H])C=3C(=O)O[H])=NN4C([H])([H])[H]
Formula:	C₃₅H₃₄ClN₅O₃S₂
M.Wt:	672.2592
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

AZD 5991 (AZD5991) is a potent and selective macrocyclic inhibitor of Mcl-1 with sub-nanomolar affinity; promotes rapid apoptosis in Mcl-1-dependent cell lines (GI50=10 nM in multiple myeloma cell lines), disrupts Mcl-1/Bak complex; completely causes tumor regression in several mouse xenograft models after a single tolerated dose. Blood Cancer Phase 1 Clinical

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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