BC-1215|CAS 1507370-20-8|DC Chemicals

Cas No.:	1507370-20-8
Chemical Name:	N1,N2-bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine
Synonyms:	BC 1215;BC1215
SMILES:	N1C=CC=CC=1C1C=CC(CNCCNCC2C=CC(C3C=CC=CN=3)=CC=2)=CC=1
Formula:	C₂₆H₂₆N₄
M.Wt:	394.522
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Chen BB, et al. A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulateinflammation. Nat Immunol. 2013 May;14(5):470-9.

Description:

BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release). BC-1215 decreases Fbxo3-Fbxl2 interaction and prevents SCFFbxo3 catalyzed Fbxl2 ubiquitination. BC-1215 inhibits the Fbxo3-TRAF activation pathway by destabilizing TRAF1–TRAF6. BC-1215, interacts with ApaG to profoundly inhibit secretion of a broad spectrum of TH1 panel cytokines from human PBMC[1].

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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