DDD 85646|DDD85646

Cas No.:	1215010-55-1
Chemical Name:	DDD85646
Synonyms:	DDD85646;2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide;MMV688180;2,6-Dichloro-4-(2-(piperazin-1-yl)pyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide;2,6-Dichloro-4-(2-Piperazin-1-Ylpyridin-4-Yl)-N-(1,3,5-Trimethyl-1h-Pyrazol-4-Yl)benzenesulfonamide;2,6-dichloro-4-(2-piperazin-1-ylpyridin-4-yl)-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamide;2,6-dichloro-4-[2;CHEMBL1230468;EX-A9381;SR-05000022657;compound 1a [PMID: 24451586];PCLX 002;AC-36960;SCHEMBL16496785;IMP-366;CS-0023728;DTX5CVK89G;IMP 366;US9156811, DDD85646;2,6-Dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide;2,6-dichloro-4-[2-(piperazin-1-yl)pyridin-4-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzene-1-sulfonamide;1215010-55-1;UNII-DTX5CVK89G;BCP28646;PCLX-002;SR-05000022657-1;BDBM184848;BDBM50364113;MS-29199;Benzenesulfonamide, 2,6-dichloro-4-(2-(1-piperazinyl)-4-pyridinyl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-;DDD 85646;2,6-dichloro-4-[2-(piperazin-1-yl)pyridin-4-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide;AKOS040748226;DDD-85646;DDD85646 Hydrochloride;Q27456208;2,6-Dichloro-4-(2-(1-piperazinyl)-4-pyridinyl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide;DTXSID701347812;HY-103056;GTPL11455;DB-422552
SMILES:	ClC1C=C(C=C(C=1S(NC1C(C)=NN(C)C=1C)(=O)=O)Cl)C1C=CN=C(C=1)N1CCNCC1
Formula:	C₂₁H₂₄Cl₂N₆O₂S
M.Wt:	495.425260543823
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

DDD 85646 is a potent, specific, dual N-Myristoyltransferase NMT1/NMT2 inhibitor with IC50 of 17 nM/22 nM respectively; inhibits myristoylation of an overexpressed protein construct in-cell-based microscopy assays; has no significant affect protein synthesis in cells; causes complete inhibition of N-myristoylation in cells at 1-10 uM; induces ER-stress, cell cycle arrest, and apoptosis in cancer cells.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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