GATA4-IN-3|CAS 544681-96-1|DC Chemicals

Cas No.:	544681-96-1
Chemical Name:	GATA4-NKX2-5-IN-1
Synonyms:	4-Isoxazolecarboxamide, N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-;GATA4-IN-3 (GATA4 inhibitor 3);GATA4-IN-3;N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-4-isoxazolecarboxamide;GATA4-NKX2-5-IN-1;N-[4-(Diethylamino)phenyl]-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide;3i-1000;Z28150190;DA-53521;CHEMBL361366;AKOS001120472;EU-0016645;HY-103484;TS-07813;G13198;BDBM50161047;5-Methyl-3-phenyl-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide;544681-96-1;N-[4-(diethylamino)phenyl]-5-methyl-3-phenylisoxazole-4-carboxamide;SCHEMBL19995013;CS-0027989;EN300-18117205;TQR1120;BCP25925;AK-968/15612676;Oprea1_612719;CCG-325450;STK437853;EX-A4534;N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide
SMILES:	CC1=C(C(NC2=CC=C(N(CC)CC)C=C2)=O)C(C3=CC=CC=C3)=NO1
Formula:	C₂₁H₂₃N₃O₂
M.Wt:	349.426
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A novel small molecule that inhibits GATA4/NKX2-5 transcriptional synergy with IC50 of 3 uM, with no activity on the protein kinases involved in the regulation of GATA4 phosphorylation; also inhibits the ET-1-stimulated BNP gene expression, and inhibits hypertrophic growth in a cardiomyocyte hypertrophy model, without effect on apoptotic cell death.

MSDS

COA

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2018-0101

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