JNJ 39758979|JNJ-39758979;JNJ39758979

Cas No.:	1046447-90-8
Chemical Name:	JNJ-39758979
Synonyms:	JNJ-39758979;jnj39758979;4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-6-PROPAN-2-YLPYRIMIDIN-2-AMINE;JNJ 39758979 (JNJ-39758979;2-Pyrimidinamine, 4-[(3R)-3-amino-1-pyrrolidinyl]-6-(1-methylethyl)-;(R)-4-(3-aminopyrrolidin-1-yl)-6-isopropylpyrimidin-2-amine;agranulocytosis,histamine,JNJ-39758979,selective,toxicity,JNJ39758979,cAMP,inhibit,oral,Histamine Receptor,anti-inflammatory,Inhibitor,antipruritic,JNJ 39758979;MFCD28502028;MFCD28502028;JNJ-39758979, (-)-;JNJ-39758979, (-)-;4-((3R)-3-aminopyrrolidin-1-yl)-6-propan-2-ylpyrimidin-2-amine;4-((3R)-3-aminopyrrolidin-1-yl)-6-propan-2-ylpyrimidin-2-amine;CS-0020957;CS-0020957;BDBM50006789;BDBM50006789;1046447-90-8;1046447-90-8;JNJ 39758979 [WHO-DD];JNJ 39758979 [WHO-DD];2-Pyrimidinamine, 4-((3R)-3-amino-1-pyrrolidinyl)-6-(1-methylethyl)-;2-Pyrimidinamine, 4-((3R)-3-amino-1-pyrrolidinyl)-6-(1-methylethyl)-;4-[(3R)-3-aminopyrrolidin-1-yl]-6-propan-2-ylpyrimidin-2-amine;4-[(3R)-3-aminopyrrolidin-1-yl]-6-propan-2-ylpyrimidin-2-amine;GLXC-04851;GLXC-04851;WRB44790;WRB44790;MS-23237;MS-23237;SCHEMBL604514;SCHEMBL604514;JNJ 39758979;JNJ 39758979;(r)-4-(3-amino-pyrrolidin-1-yl)-6-isopropyl-pyrimidin-2-ylamine;(r)-4-(3-amino-pyrrolidin-1-yl)-6-isopropyl-pyrimidin-2-ylamine;4-[(3R)-3-aminopyrrolidin-1-yl]-6-isopropylpyrimidin-2-amine;4-[(3R)-3-aminopyrrolidin-1-yl]-6-isopropylpyrimidin-2-amine;HY-101189;HY-101189;GTPL8984;GTPL8984;UNII-5RV7T5BNMG;UNII-5RV7T5BNMG;Q27888282;Q27888282;JNJ-39758979 [WHO-DD];JNJ-39758979 [WHO-DD];4-[(3R)-3-aminopyrrolidin-1-yl]-6-(propan-2-yl)pyrimidin-2-amine;4-[(3R)-3-aminopyrrolidin-1-yl]-6-(propan-2-yl)pyrimidin-2-amine;AKOS030628488;AKOS030628488;5RV7T5BNMG;5RV7T5BNMG;CHEMBL3236549;CHEMBL3236549
SMILES:	C1(N)=NC(C(C)C)=CC(N2CC[C@@H](N)C2)=N1
Formula:	C₁₁H₁₉N₅
M.Wt:	221.302061319351
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent, selective, orally bioavailable histamine H4 receptor antagonist with Ki of 12.5 nM, >80-fold selectivity over other histamine receptors; shows dose-dependent activity in models of asthma and dermatitis, has good pharmacokinetics.AsthmaPhase 2 Clinical

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
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DC74555	GYS32661	GYS32661 (GYS 32661) is a potent Rac inhibitor capable of inhibiting both Rac1 and Rac1b, inhibited activated Rac1 with IC50 of 1.18 uM in in vitro pull-down assays.
DC74539	L557-0155	L557-0155 is a small molecule inhibitor of VSIG-8, prevents VSIG-8 binding to VISTA, promotes cytokine production and cell proliferation in PBMCs and suppresses melanoma growth.
DC74528	K284	K284 is a selective small molecule inhibitor of chitinase 3 like1 (CHI3L1) with strong binding affinity (Kd=-9.7 kcal·mol-1), inhibits lung metastasis by blocking IL-13Rα2-mediated JNK-AP-1 signals.
DC74225	YB-537	YB-537 (YB537) is a potent, highly specific quinone reductase 2 (QR2) inhibitor with IC50 of 3 nM, shows no activity against QR1 (IC50>10 uM).
DC74223	X-Neu5Ac	X-Neu5Ac (sodium) is a substrate for chromogenic assay of neuraminidase activity in bacterial expression systems; with a Km of 0.89 mM for neuraminidase.
DC74218	UT-59	UT-59 is a specific inhibitor of cholesterol-sensing membrane protein Scap, binds to Scap's cholesterol-binding site, blocks SREBP activation and inhibits lipid synthesis.
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DC74203	TR-107	TR-107 (TR107) is a highly potent, selective and orally bioavailable small-molecule activator of the mitochondrial protease ClpP with EC50 of 140 nM, binds to purified ClpP with Kd value of 180 nM in surface plasmon resonance (SPR) measurement.