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Home > RNA Delivery > Adjuvant Molecules > TLR agonist small molecule

Telratolimod

  Cat. No.:  DC21273   Featured
Chemical Structure
1359993-59-1
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More than 5000 active chemicals with high quality for research!
Field of application
Telratolimod (MEDI 9197, 3M 052) is a novel, injectable, tissue-retained TLR7/8 agonist that forms a tissue depot with gradual, sustained release, allowing local TLR triggering activity without systemic cytokine release.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1359993-59-1
Chemical Name: N-{4-[(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)oxy]butyl}octadecanamide
Synonyms: MEDI 9197;3M 052
SMILES: NC1C2N=C(N(OCCCCNC(=O)CCCCCCCCCCCCCCCCC)C=2C2C(=CC=CC=2)N=1)CCCC
Formula: C36H59N5O2
M.Wt: 593.885969400406
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Zhao BG, et al. Combination therapy targeting toll like receptors 7, 8 and 9 eliminates large established tumors. J Immunother Cancer. 2014 May 13;2:12.
Description: Telratolimod is a toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity.
Target: TLR7/8[1]
In Vivo: Telratolimod (50 μg) inhibits the tumor volume, and more potently blocks tumor gowth in combination with CpG ODN in BALB/c mice bearing CT26 colon carcinoma cells. Telratolimod (100 μg) plus 200 μg of CpG ODN slows tumor growth and prolongs survival of mice bearing large tumors[1].
In Vitro: Telratolimod (3M-052) is a toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity[1].
References: [1]. Zhao BG, et al. Combination therapy targeting toll like receptors 7, 8 and 9 eliminates large established tumors. J Immunother Cancer. 2014 May 13;2:12.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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