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BI-1467335 HCl

  Cat. No.:  DC21546   Featured
Chemical Structure
1478364-68-9
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Field of application
BI 1467335 (PXS-4728A, PXS-4728) is a potent, selective, orally active SSAO/VAP-1 (AOC3) inhibitor with IC50 of 5 nM; displays >500-fold selective for VAP-1/SSAO over all the related human amine oxidases; diminishes leukocyte rolling and adherence induced by CXCL1/KC, also inhibits the migration of neutrophils to the lungs in response to LPS, Klebsiella pneumoniae lung infection and CLP induced sepsis.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1478364-68-9
Chemical Name: (E)-4-((2-(aminomethyl)-3-fluoroallyl)oxy)-N-(tert-butyl)benzamide hydrochloride
Synonyms: PXS-4728A; PXS4728A; PXS 4728A; BI-1467335; BI 1467335; BI1467335; BI-1467335 HCl; BI-1467335 hydrochloride
SMILES: Cl.NC/C(/COC1=CC=C(C(NC(C)(C)C)=O)C=C1)=C\F
Formula: C15H21FN2O2.HCl
M.Wt: 316.8
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: 1. Schilter HC, et al. Respir Res. 2015 Mar 20;16:42. 2. Jarnicki AG, et al. Br J Pharmacol. 2016 Nov;173(22):3161-3175. 3. Katagiri D, et al. Respir Res. 2015 Mar 20;16:42.
Description: BI 1467335 (PXS-4728A, PXS-4728) is a potent, selective, orally active SSAO/VAP-1 (AOC3) inhibitor with IC50 of 5 nM; displays >500-fold selective for VAP-1/SSAO over all the related human amine oxidases; diminishes leukocyte rolling and adherence induced by CXCL1/KC, also inhibits the migration of neutrophils to the lungs in response to LPS, Klebsiella pneumoniae lung infection and CLP induced sepsis.
Target: SSAO[1]
References: [1]. A G Jarnicki, et al. The Inhibitor of Semicarbazide-Sensitive Amine Oxidase, PXS-4728A, Ameliorates Key Features of Chronic Obstructive Pulmonary Disease in a Mouse Model. Br J Pharmacol. 2016 Nov;173(22):3161-3175.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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