SHP504|CAS 2222280-83-1|allosteric site 2 SHP2 inhibitor|DC Chemicals

Cas No.:	2222280-83-1
Chemical Name:	3-(4-(2-chlorobenzyl)-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl)-4-hydroxybenzoic acid
Synonyms:	SHP 504;SHP-504;SHP504
SMILES:	C(O)(=O)C1=CC=C(O)C(C2N3C4=C(C=CC=C4)C(=O)N(CC4=CC=CC=C4Cl)C3=NN=2)=C1
Formula:	C₂₃H₁₅ClN₄O₄
M.Wt:	446.847
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Fodor M, et al. ACS Chem Biol. 2018 Jan 18. doi: 10.1021/acschembio.7b00980.

Description:

SHP504 is a distinct, allosteric site 2 SHP2 inhibitor with IC50 of 21 uM (SHP2 1-525), and selective over the phosphatase domain (SHP2 PTP IC50>100 uM).downregulates DUSP6 mRNA, a downstream MAPK pathway marker, in KYSE-520 cancer cells; enhances pharmacological pathway inhibition in cells combined with SHP099.

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2018-0101

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