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CD73 inhibitor AB-680

  Cat. No.:  DC21981   Featured
Chemical Structure
2105904-82-1
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More than 5000 active chemicals with high quality for research!
Field of application
AB680 (AB-680) is a highly potent, selective, reversible inhibitor of CD73 with Ki/IC50 of 4.9/70 pM (hCD73), displays > 10,000-fold selectivity against related ecto-nucleotidases (CD39, NTPDases 2/3/8) and a large panel of unrelated enzymes, receptors, a
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2105904-82-1
Chemical Name: CID 130205852
Synonyms: J6K8WSV73A;GTPL10707;AB680;[[(2R,3S,4R,5R)-5-[6-chloro-4-[[(1S)-1-(2-fluorophenyl)ethyl]amino]pyrazolo[3,4-b]pyridin-1-yl]-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]methylphosphonic acid;(((((2R,3S,4R,5R)-5-(6-chloro-4-(((S)-1-(2-fluorophenyl)ethyl)amino)-1H-pyrazolo[3,4-b]pyridin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)methyl)phosphonic acid;CID 130205852 AB 680
SMILES: ClC1C([H])=C(C2C([H])=NN(C=2N=1)[C@@]1([H])[C@@]([H])([C@@]([H])([C@@]([H])(C([H])([H])OP(C([H])([H])P(=O)(O[H])O[H])(=O)O[H])O1)O[H])O[H])N([H])[C@@]([H])(C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1F
Formula: C20H24ClFN4O9P2
M.Wt: 580.824889183044
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Lawson KV, et al. Discovery and Characterization of AB680, a Potent and Selective Small-Molecule CD73 Inhibitor for Cancer Immunotherapy.
Description: AB-680 is highly potent, reversible and selective small molecule inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity[1].
In Vitro: AB-680 (AB680) inhibits soluble hCD73 with an IC50 of 0.043 nM, also inhibits hCD73 in CHO cells, suppresses CD73 in human, mouse CD8+ T Cells and hPBMC, with IC50s of 0.070, 0.008, 0.66 and 0.011 nM, respectively[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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