NAPQI| CAS 50700-49-7|DC Chemicals

Cas No.:	50700-49-7
Chemical Name:	N-ACETYL-4-BENZOQUINONE IMINE
Synonyms:	N-ACETYL-4-BENZOQUINONE IMINE;N-(4-Oxo-1-cyclohexa-2,5-dienylidene)acetamide,N-Acetyl-p-benzo-quinoneimine,NAPQI;N-(4-oxocyclohexa-2,5-dien-1-ylidene)acetamide;N-(4-Oxo-1-cyclohexa-2,5-dienylidene)acetamide;NAPQI;N-Acetyl-1,4-benzoquinonimine;N-Acetyl-p-benzoquinone imine;N-Acetyl-p-benzoquinonimine;2,5-Cyclohexadien-1-one,4-(acetylimino)-
SMILES:	C(/N=C1\C=CC(=O)C=C\1)(=O)C
Formula:	C₈H₇NO₂
M.Wt:	149.146682024002
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A toxic byproduct, iminoquinone metabolite of acetaminophen that covalently binds to the active site of MIF; inhibits both the isomerase and the biological activities of MIF with IC50 of 40 uM; significantly inhibits the ability of MIF to override the immunosuppressive effect of dexamethasone on endotoxin- (LPS) stimulated TNFα production by monocytes.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
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DC31074	Isopropyl myristate	Isopropyl myristate is the ester of isopropyl alcohol and myristic acid.
DC74557	PREX-in1	PREX-in1 is a specific small-molecule inhibitor of P-Rex1 and P-Rex2 Rac-GEF activity with IC50 of 4.5 uM (P-Rex1 DHPH Rac-GEF activity) in liposome-based GEF assay, inhibits P-Rex1 and P-Rex2 through their catalytic DH domain.
DC74555	GYS32661	GYS32661 (GYS 32661) is a potent Rac inhibitor capable of inhibiting both Rac1 and Rac1b, inhibited activated Rac1 with IC50 of 1.18 uM in in vitro pull-down assays.
DC74539	L557-0155	L557-0155 is a small molecule inhibitor of VSIG-8, prevents VSIG-8 binding to VISTA, promotes cytokine production and cell proliferation in PBMCs and suppresses melanoma growth.
DC74528	K284	K284 is a selective small molecule inhibitor of chitinase 3 like1 (CHI3L1) with strong binding affinity (Kd=-9.7 kcal·mol-1), inhibits lung metastasis by blocking IL-13Rα2-mediated JNK-AP-1 signals.
DC74225	YB-537	YB-537 (YB537) is a potent, highly specific quinone reductase 2 (QR2) inhibitor with IC50 of 3 nM, shows no activity against QR1 (IC50>10 uM).
DC74218	UT-59	UT-59 is a specific inhibitor of cholesterol-sensing membrane protein Scap, binds to Scap's cholesterol-binding site, blocks SREBP activation and inhibits lipid synthesis.
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DC74198	TMX-4102	TMX-4102 (TMX4102) is a highly potent, selective PIP4K2C binder with KD of 0.45 nM, shows no affinity for PIP4K2B and PIP4K2A (KD>10 uM).