3-Bromopyruvic acid| CAS 1113-59-3

Cas No.:	1113-59-3
Chemical Name:	3-Bromopyruvic acid
Synonyms:	3-Bromopyruvic acid;3-BROMO-2-OXOPROPANOIC ACID;3-BROMO-2-OXOPROPIONIC ACID;BROMOPYRUVIC ACID;3-bromo-2-oxo-propanoicaci;3-bromopyruvate;beta-bromopyruvicacid;bromopyruvate;bromo-pyruvicaci;3-BROMOPYRUVIC ACID CRYSTALLINE;Bromopyruvicacidhydrate;3-BROMO-2-OXOPROPANOICACID(3-BROMOPYRUVICACID);2-Oxo-3-bromopropanoic acid;2-Oxo-3-bromopropionic acid;3-BROMO-2-OXO-PROPIONIC ACID;3-BromopYHuvic acid;3-BROMOPYRUVIC ACID HYDRATE;3-BROMOPYRUVICACID(3-BROMOPYRUVATE);Hexokinase II Inhibitor II, 3-BP;PROPANOIC ACID,3-BROMO-2-OXO-;3-Bromo-2-oxopropionic Acid;NS00023565;NS00023565;EN300-67360;EN300-67360;CHEBI:95046;CHEBI:95046;Bromopyruvic acid; 3-bromo-2-oxopropanoic acid;Bromopyruvic acid; 3-bromo-2-oxopropanoic acid;Bromopyruvic acid, >=97.0% (T);Bromopyruvic acid, >=97.0% (T);3-bromo-2-oxopropanoic acid;3-Bromopyruvic acid;3-bromo-2-oxopropanoic acid;3-Bromopyruvic acid;bromopyruvic acid;bromopyruvic acid;3-BP;3-BP;.beta.-Bromopyruvic acid;NSC-62343;.beta.-Bromopyruvic acid;NSC-62343;EINECS 214-206-5;NSC 11731;EINECS 214-206-5;NSC782120;NSC 11731;FT-0623262;NSC782120;BRD-K92980438-001-01-7;FT-0623262;BRD-K92980438-001-01-7;Z1079181768;Z1079181768;Bromopyruvicacid;Bromopyruvicacid;Hexokinase II Inhibitor II, 3-BP - CAS 1113-59-3;Hexokinase II Inhibitor II, 3-BP - CAS 1113-59-3;3-Bromo-2-oxopropionic acid;3-Bromo-2-oxopropionic acid;NSC-11731;NSC-11731;Propanoic acid, 3-bromo-2-oxo-;3-bromo-2-oxo-propionic acid;Propanoic acid, 3-bromo-2-oxo-;J-650255;3-bromo-2-oxo-propionic acid;J-650255;1113-59-3;1113-59-3;BPV;BPV;CS-5517;NSC11731;CS-5517;Q3608257;NSC11731;NSC62343;Q3608257;3-BrPA;NSC62343;MFCD00002587;3-BrPA;Pyruvic acid, bromo-;HY-19992;MFCD00002587;3-Bromopyruvic acid hydrate,98;Pyruvic acid, bromo-;HY-19992;B1153;SCHEMBL8126;3-Bromopyruvic acid hydrate,98;bromo-2-oxopropanoic acid;B1153;beta-Bromopyruvic acid;SCHEMBL8126;s5426;bromo-2-oxopropanoic acid;AM84337;beta-Bromopyruvic acid;AS-16146;s5426;AKOS015892643;AM84337;63JMV04GRK;AS-16146;NSC 62343;AKOS015892643;63JMV04GRK;3-bromopyruvic acid;HMS3866H13;NSC 62343;CCG-266336;3-bromopyruvic acid;Hexokinase II Inhibitor II;3-BP;HMS3866H13;J-511892;CCG-266336;UNII-63JMV04GRK;Hexokinase II Inhibitor II;3-BP;BRN 1746786;J-511892;3-Bromo-2-oxopropanoic acid #;UNII-63JMV04GRK;CHEBI:131461;BRN 1746786;3-bromo-2-oxopropanoic acid;3-Bromo-2-oxopropanoic acid #;3-bromo-2-keto-propionic acid;CHEBI:131461;NSC-782120;3-bromo-2-oxopropanoic acid;HMS3741K19;3-bromo-2-keto-propionic acid;3-bromopyruvicacid;NSC-782120;DTXSID7040940;HMS3741K19;CHEMBL177837;3-bromopyruvicacid;NCIOpen2_000241;DTXSID7040940;CHEMBL177837;NCIOpen2_000241
SMILES:	O=C(O)C(CBr)=O
Formula:	C₃H₃BrO₃
M.Wt:	166.96
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A glycolytic inhibitor that inhibits hexokinase II activity, suppresses ATP production, and induces endoplasmic reticulum (ER) stress; potentiates acetate-induced apoptosis and anti-proliferative effect in CRC cells; abrogates MUC1-mediated radiation resistance both in vitro and in vivo pancreatic cancer models, by reducing glucose flux into nucleotide biosynthetic pathways and enhancing DNA damage.

MSDS

COA

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2018-0101

Cat. No.	Product name	Field of application
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DC31074	Isopropyl myristate	Isopropyl myristate is the ester of isopropyl alcohol and myristic acid.
DC74557	PREX-in1	PREX-in1 is a specific small-molecule inhibitor of P-Rex1 and P-Rex2 Rac-GEF activity with IC50 of 4.5 uM (P-Rex1 DHPH Rac-GEF activity) in liposome-based GEF assay, inhibits P-Rex1 and P-Rex2 through their catalytic DH domain.
DC74555	GYS32661	GYS32661 (GYS 32661) is a potent Rac inhibitor capable of inhibiting both Rac1 and Rac1b, inhibited activated Rac1 with IC50 of 1.18 uM in in vitro pull-down assays.
DC74539	L557-0155	L557-0155 is a small molecule inhibitor of VSIG-8, prevents VSIG-8 binding to VISTA, promotes cytokine production and cell proliferation in PBMCs and suppresses melanoma growth.
DC74528	K284	K284 is a selective small molecule inhibitor of chitinase 3 like1 (CHI3L1) with strong binding affinity (Kd=-9.7 kcal·mol-1), inhibits lung metastasis by blocking IL-13Rα2-mediated JNK-AP-1 signals.
DC74225	YB-537	YB-537 (YB537) is a potent, highly specific quinone reductase 2 (QR2) inhibitor with IC50 of 3 nM, shows no activity against QR1 (IC50>10 uM).
DC74218	UT-59	UT-59 is a specific inhibitor of cholesterol-sensing membrane protein Scap, binds to Scap's cholesterol-binding site, blocks SREBP activation and inhibits lipid synthesis.
DC74205	Tryptolinamide	Tryptolinamide (TLAM) is a small-molecule compound that activates mitochondrial respiration in cybrids generated from patient-derived mitochondria and fibroblasts from patient-derived iPSCs, inhibits phosphofructokinase-1 (PFK1) with an ATP-uncompetitive
DC74198	TMX-4102	TMX-4102 (TMX4102) is a highly potent, selective PIP4K2C binder with KD of 0.45 nM, shows no affinity for PIP4K2B and PIP4K2A (KD>10 uM).