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SMAP

  Cat. No.:  DC22537   Featured
Chemical Structure
1809427-18-6
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More than 5000 active chemicals with high quality for research!
Field of application
SMAP (DT-061, DT061) is an orally bioavailable small molecule activator of PP2A, inhibits KRAS-driven tumor growth.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1809427-18-6
Chemical Name: N-((1R,2R,3S)-2-Hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl)-4-(trifluoromethoxy)benzenesulfonamide
Synonyms: SMAP;s8774;L2J;N-((1R,2R,3S)-2-Hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl)-4-(trifluoromethoxy)benzenesulfonamide
SMILES: S(C1C=CC(=CC=1)OC(F)(F)F)(N[C@@H]1CCC[C@@H]([C@H]1O)N1C2C=CC=CC=2OC2C=CC=CC1=2)(=O)=O
Formula: C25H23F3N2O5S
M.Wt: 520.52073597908
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: SMAP (DT-061, DT061) is an orally bioavailable small molecule activator of PP2A, inhibits KRAS-driven tumor growth; acts by binding to the PP2A Aα scaffold subunit to drive conformational changes in PP2A; inhibits the growth of KRAS-mutant lung cancers in mouse xenografts and transgenic models.
References: References 1. Sangodkar J, et al. J Clin Invest. 2017 Jun 1;127(6):2081-2090. 2. Kauko O, et al. Sci Transl Med. 2018 Jul 18;10(450). pii: eaaq1093. View Related Products by Target Protein Phosphatase/PTP
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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