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Fezolinetant

  Cat. No.:  DC22664   Featured
Chemical Structure
1629229-37-3
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More than 5000 active chemicals with high quality for research!
Field of application
Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1629229-37-3
Chemical Name: Fezolinetant
Synonyms: Fezolinetant;83VNE45KXX;ESN364;(R)-(4-fluorophenyl)(8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone;Fezolinetant [USAN];GTPL10422;BDBM50112244;WHO 10205;compound 3 [PMID:26191358];SB19658;Q27269455;(4-fluorophenyl)-[(8R)-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone;Methanone, ((8R)-5,6-
SMILES: S1C(C2=NN=C3[C@@H](C)N(C(C4C=CC(=CC=4)F)=O)CCN32)=NC(C)=N1
Formula: C16H15FN6Os
M.Wt: 358.393304109573
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Fraser GL, et al. The NK3 Receptor Antagonist ESN364 Interrupts Pulsatile LH Secretion and Moderates Levels of Ovarian Hormones Throughout the Menstrual Cycle. Endocrinology. 2015 Nov;156(11):4214-25.
Description: Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes.
References: [1]. Fraser GL, et al. The NK3 Receptor Antagonist ESN364 Interrupts Pulsatile LH Secretion and Moderates Levels of Ovarian Hormones Throughout the Menstrual Cycle. Endocrinology. 2015 Nov;156(11):4214-25.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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