FPH 2(BRD9424)

Cas No.:	957485-64-2
Chemical Name:	4-(3-(5-Chloro-2-methoxyphenyl)thioureido)-1-ethyl-1H-pyrazole-3-carboxamide
Synonyms:	FPH2(BRD-9424);1H-​Pyrazole-​3-​carboxamide, 4-​[[[(5-​chloro-​2-​methoxyphenyl)​amino]​thioxomethyl]​amino]​-​1-​ethyl-;BRD 9424;BRD-9424;FPH 2;FPH-2;4-(3-(5-Chloro-2-methoxyphenyl)thioxureido)-1-ethyl-1H-pyrazole-3-carboxamide;4-[[[(5-Chloro-2-methoxyphenyl)amino]thioxomethyl]amino]-1-ethyl-1H-pyrazole-3-carboxamide;FPH2;4-(3-(5-Chloro-2-methoxyphenyl)thioureido)-1-ethyl-1H-pyrazole-3-carboxamide;BRD9424;4-[(5-chloro-2-methoxyphenyl)carbamothioylamino]-1-ethylpyrazole-3-carboxamide;4-{[(5-chloro-2-methoxyphenyl)carbamothioyl]amino}-1-ethyl-1H-pyrazole-3-carboxamide;4-[[(5-chloro-2-methoxyanilino)-sulfanylidenemethyl]amino]-1-ethyl-3-pyrazolecarboxamide;CBKinase1_006299;CBK
SMILES:	ClC1C([H])=C([H])C(=C(C=1[H])N([H])C(N([H])C1C(C(N([H])[H])=O)=NN(C=1[H])C([H])([H])C([H])([H])[H])=S)OC([H])([H])[H]
Formula:	C14H16ClN5O2S
M.Wt:	353.8271
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	FPH2 induces of functional proliferation of primary human hepatocytes and may lead to the development of new therapeutics for liver diseases.
In Vitro:	FPH2 induces functional proliferation of hepatocytes in vitro, and thus may be useful for expanding mature human primary hepatocytes. FPH1 and FPH2 can increase in hepatocyte nuclei count and/or elevate the number of nuclei undergoing mitosis during primary screening, and these effects on hepatocytes are concentration dependent. Cells treated with FPH1 and FPH2 also maintain their liver-specific functions. Over 7 days, FPH2 induces hepatocyte doublings at a rate that is consistent with reported liver regeneration kinetics in vivo[1].
References:	[1]. Shan J, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nat Chem Biol. 2013 Aug;9(8):514-20.