Damnacanthal

  Cat. No.:  DC22810  
Chemical Structure
477-84-9
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More than 5000 active chemicals with high quality for research!
Field of application
Damnacanthal is a highly potent, selective inhibitor of p56 lck tyrosine kinase with IC50 of 17 nM for inhibition of p56lck autophosphorylation.
Cas No.: 477-84-9
Chemical Name: 3-hydroxy-1-methoxy-9,10-dioxo-9,10-dihydroanthracene-2-carbaldehyde
SMILES: OC1=CC2=C(C(=O)C3C(C2=O)=CC=CC=3)C(OC)=C1C=O
Formula: C16H10O5
M.Wt: 282.25
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Damnacanthal is a highly potent, selective inhibitor of p56 lck tyrosine kinase with IC50 of 17 nM for inhibition of p56lck autophosphorylation; also shows an IC50 of 620 nM for phosphorylation of an exogenous peptide by p56lck; displays >100-fold selectivity over PKA and PKC, modest (7-20-fold) over p60src and p59fyn; inhibits PMACI-induced IL-1β, IL-6 and TNF-α expressions by suppressing NF-κB activation and suppresses the activation of caspase-1 and the expression of RIP-2 in mast cells; also is an effective inhibitor of LIMK1/2 (IC50=0.8/1.53 uM, respectively).
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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DC47247 Tyrosylleucine TFA Tyrosylleucine (Tyr-Leu, YL) TFA, an orally active dipeptide, exhibits a potent antidepressant-like activity.
DC47243 Dehydroglyasperin C Dehydroglyasperin C, a isoflavone, is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C has antioxidant, neuroprotective, cancer chemopreventive, and anti-inflammatory activities.
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DC47224 GPX4-IN-3 GPX4-IN-3 (26a) is a potent glutathione peroxidase 4 (GPX4) inhibitor as a selective ferroptosis inducer. GPX4-IN-3 (26a) exhibits 71.7% inhibition for GPX4 with 1 μM.
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DC47140 Yadanzioside K Yadanzioside K is a natural quassinoid glucoside found in Brucea amarissima.
DC47105 Complanatoside B Complanatoside B is a P. chinense Fisch flavonoid with potential anti-inflammatory effects.
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