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GB111-NH2

  Cat. No.:  DC22975   Featured
Chemical Structure
956479-18-8
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Field of application
GB111-NH2 (Z-Phe-Lys-AOMK) is a novel cysteine cathepsin inhibitor that blocks the activity of cathepsins B, L and S. GB111-NH2 (Z-Phe-Lys-AOMK) inhibits autophagy and increases oxidative stress, specifically trigger macrophage cell death.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 956479-18-8
Chemical Name: GB111-NH2
SMILES: C(N)CCC[C@H](NC(=O)[C@@H](NC(=O)OCC1C=CC=CC=1)CC1C=CC=CC=1)C(=O)COC(=O)C1=C(C)C=CC=C1C
Formula: C33H39N3O6
M.Wt: 573.68
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: 1. Salpeter SJ, et al. Oncogene. 2015 Dec 10;34(50):6066-78. 2. Blum G, et al. Nat Chem Biol. 2005 Sep;1(4):203-9.
Description: GB111-NH2 (Z-Phe-Lys-AOMK) is a novel cysteine cathepsin inhibitor that blocks the activity of cathepsins B, L and S. GB111-NH2 (Z-Phe-Lys-AOMK) inhibits autophagy and increases oxidative stress, specifically trigger macrophage cell death.
References: 1. Salpeter SJ, et al. Oncogene. 2015 Dec 10;34(50):6066-78. 2. Blum G, et al. Nat Chem Biol. 2005 Sep;1(4):203-9.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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