HO-3867| CAS 1172133-28-6

Cas No.:	1172133-28-6
Chemical Name:	(3E,5E)-3,5-bis[(4-fluorophenyl)methylidene]-1-[(1-hydroxy-2,2,5,5-tetramethylpyrrol-3-yl)methyl]piperidin-4-one
Synonyms:	HO-3867;4-Piperidinone, 1-[(2,5-dihydro-1-hydroxy-2,2,5,5-tetramethyl-1H-pyrrol-3-yl)methyl]-3,5-bis[(4-fluorophenyl)methylene]-, (3E,5E)-;HO 3867;(3E,5E)-3,5-bis(4-fluorobenzylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one;C28H30F2N2O2;(3E,5E)-3,5-bis[(4-fluorophenyl)methylidene]-1-[(1-hydroxy-2,2,5,5-tetramethylpyrrol-3-yl)methyl]piperidin-4-one;2463AH;s7501;A14264;(3E,5E)-3,5-bis[(4-fluorophenyl)methylidene]-1-[(1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl]piperidin-4-one;CID 46871899;XWB13328;HO3867
SMILES:	FC1C([H])=C([H])C(=C([H])C=1[H])/C(/[H])=C1/C(/C(=C(\[H])/C2C([H])=C([H])C(=C([H])C=2[H])F)/C([H])([H])N(C/1([H])[H])C([H])([H])C1=C([H])C(C([H])([H])[H])(C([H])([H])[H])N(C1(C([H])([H])[H])C([H])([H])[H])O[H])=O
Formula:	C₂₈H₃₀F₂N₂O₂
M.Wt:	464.5468
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A synthetic curcuminoid that selectively inhibits STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs; induces G2-M cell cycle arrest in A2780 cells by modulating cell cycle regulatory molecules p53, p21, p27, CDK 2, and cyclin, and promotes apoptosis, inhibits pSTAT3 (Tyr705 and Ser727) and JAK1 and increases apoptotic markers cleaved caspase-3 and PARP in xenograft tumor tissues.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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