HO-3867

  Cat. No.:  DC23209   Featured
Chemical Structure
1172133-28-6
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More than 5000 active chemicals with high quality for research!
Field of application
A synthetic curcuminoid that selectively inhibits STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs.
Cas No.: 1172133-28-6
Chemical Name: (3E,5E)-3,5-bis[(4-fluorophenyl)methylidene]-1-[(1-hydroxy-2,2,5,5-tetramethylpyrrol-3-yl)methyl]piperidin-4-one
Synonyms: HO-3867;4-​Piperidinone, 1-​[(2,​5-​dihydro-​1-​hydroxy-​2,​2,​5,​5-​tetramethyl-​1H-​pyrrol-​3-​yl)​methyl]​-​3,​5-​bis[(4-​fluorophenyl)​methylene]​-​, (3E,​5E)​-;HO 3867;(3E,5E)-3,5-bis(4-fluorobenzylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one;C28H30F2N2O2;(3E,5E)-3,5-bis[(4-fluorophenyl)methylidene]-1-[(1-hydroxy-2,2,5,5-tetramethylpyrrol-3-yl)methyl]piperidin-4-one;2463AH;s7501;A14264;(3E,5E)-3,5-bis[(4-fluorophenyl)methylidene]-1-[(1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl]piperidin-4-one;CID 46871899;XWB13328;HO3867
SMILES: FC1C([H])=C([H])C(=C([H])C=1[H])/C(/[H])=C1/C(/C(=C(\[H])/C2C([H])=C([H])C(=C([H])C=2[H])F)/C([H])([H])N(C/1([H])[H])C([H])([H])C1=C([H])C(C([H])([H])[H])(C([H])([H])[H])N(C1(C([H])([H])[H])C([H])([H])[H])O[H])=O
Formula: C28H30F2N2O2
M.Wt: 464.5468
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A synthetic curcuminoid that selectively inhibits STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs; induces G2-M cell cycle arrest in A2780 cells by modulating cell cycle regulatory molecules p53, p21, p27, CDK 2, and cyclin, and promotes apoptosis, inhibits pSTAT3 (Tyr705 and Ser727) and JAK1 and increases apoptotic markers cleaved caspase-3 and PARP in xenograft tumor tissues.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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