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SCH-28080

  Cat. No.:  DC23626   Featured
Chemical Structure
76081-98-6
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More than 5000 active chemicals with high quality for research!
Field of application
SCH-28080 is a potent, orally active, reversible inhibitor of gastric H+,K+-ATPase with IC50 of 20 nM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 76081-98-6
Chemical Name: Imidazo[1,2-a]pyridine-3-acetonitrile,2-methyl-8-(phenylmethoxy)-
Synonyms: Imidazo[1,2-a]pyridine-3-acetonitrile,2-methyl-8-(phenylmethoxy)-;2-(2-methyl-8-phenylmethoxyimidazo[1,2-a]pyridin-3-yl)acetonitrile;2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE;SCH 28080;SCH 28080 NEW;[8-(benzyloxy)-2-methylimidazo[1,2-a]pyridin-3-yl]acetonitrile;2-Methyl-8-(phenylmethoxy)imidazo;2-methyl-8-(phenylmethoxy)-imidazo(1,2-A)-pyridine-3-acetonitrile;3-(cyanomethyl)-2-methyl-8-(phenylmethoxy)imidazopyridine;8-phenylmethoxy-2-methylimidazo[1,2-a]pyridine-3-acetonitrile;Imidazo(1,2-a)pyridine-3-acetonitrile, 2-methyl-8-(phenylmethoxy)-;Sch-28080
SMILES: N#CCC1=C(C)N=C2C(=CC=CN12)OCC1C=CC=CC=1
Formula: C17H15N3O
M.Wt: 277.320503473282
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: SCH28080 inhibits gastric H+/K+-ATPase by K+-competitive binding, with an IC50 value of 20 nM in rabbit microsomal membranes[1]. Antisecretory and cytoprotective activities[2].
Target: IC50: 20 nM (H+/K+-ATPase, rabbit microsomal membranes)[1]
References: [1]. Scott CK, et al. Studies on the mechanism of action of the gastric microsomal (H+ + K+)-ATPase inhibitors SCH 32651 and SCH 28080. Biochem Pharmacol. 1987 Jan 1;36(1):97-104. [2]. Long JF, et al. Gastric antisecretory and cytoprotective activities of SCH 28080. J Pharmacol Exp Ther. 1983 Jul;226(1):114-20.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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