TAOK inhibitor 43| CAS 850467-66-2|DC Chemicals

Cas No.:	850467-66-2
Chemical Name:	N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide
SMILES:	O=C(CNC(C1=CC=C(C2=CC=CC=C2)C=C1)=O)NC(CCC3)C4=C3C=CC=C4
Formula:	C₂₅H₂₄N₂O₂
M.Wt:	384.47
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Koo CY, et al. Mol Cancer Ther. 2017 Nov;16(11):2410-2421.

Description:

TAOK inhibitor 43 is a novel potent, selective, ATP-competitive TAO Kinase (TAOK) inhibitor with IC50 of 11 and 15 nM against TAOK1 and TAOK2, respectively; increases the mitotic population, the percentages of mitotic cells displaying amplified centrosomes and multipolar spindles, induces cell death, and inhibits cell growth in centrosome-amplified SKBR3 or BT549 breast cancer cell models.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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TAO Kinase inhibitor 1