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Cevimeline

  Cat. No.:  DC23950   Featured
Chemical Structure
107233-08-9
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More than 5000 active chemicals with high quality for research!
Field of application
Cevimeline is a parasympathomimetic and muscarinic agonist that affects M1 and M3 receptors. It is used in the treatment of dry mouth and Sjögren's syndrome. Cevimeline has also been shown to reduce Xerostomia symptoms and increase salivary flow in head and neck cancer survivors after radiotherapy.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 107233-08-9
Chemical Name: Cevimeline
Synonyms: Cevimeline;(+/-)-cis-2-Methylspiro[1,3-oxathiolane-5,3'-quinuclidine];CEVIMELINE, HYDROCHLORIDE SALT;Spiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane], 2'-methyl-, (2'R,3R)-rel-;3]oxathiolane];AF-102B;CevimelineHClSalt;Evoxac;SNI-2011;Hsdb 7286;CeviMeline(Evoxac);3R)-rel-;2-Methyspiro(1,3-oxathiol;Cevimeline (hydrochloride);Cevimeline hydrochloride;Saligren;(+-)-cis-2-Methylspiro(1,3-oxathiolan-5,3')quinuclidine hydrochloride;cis-(+-)-2'-Methylspiro(1-azabicyclo(2.2.2)octane-3,5'-(1,3)oxathiolane) hydrochloride;Spiro(1-azabicyclo(2.2.2)octane-3,5'-(1,3)oxathiolane), 2'-methyl-, hydrochloride, cis-(+-)-;SNK 508;SND 5008;Fks 508;AF 102B;cis-2'-Methylspiro(1-azabicyclo(2.2.2)octane-3,5'-(1,3)oxathiolane) hydrochloride;C10H17NOS.ClH;Cevimeline,hydrochlo;Cevimeline [INN];Cevimeline HCl;C10H17NOS;Cevimeline (INN);2-Methyspiro(1,3-oxathiolane-5,3)quinuclidine;AF102B;PubChem19118;cevimeline trans-sulfoxide;BIDD:GT0265;Spiro(1-azabicyclo(2.2.2)octane-3,5'-(1,3)-oxathiolane), 2'-methyl-, cis-;Spiro(1-azabicyclo(2.2.2)octane-3,5'-(1,3)-oxathiolane), 2'-methyl-, (2'R,3R)-rel-;DTXSID2023777;(2R)-2'-methylspiro(4-quinuclidine-2,5'-(1,3)oxathiolane);HY-70020;EN300-814007;CS-0397;(2R)-2'-methylspiro(4-azabicyclo(2.2.2)octane-2,5'-(1,3)oxathiolane);DTXSID401338115;AS-56166;HSDB 7286;CHEBI:3568;AKOS025294043;N07AX03;Sni 2011;DTXCID603777;CHEMBL1201267;NS00068154;1035535-90-0;SPIRO(1-AZABICYCLO(2.2.2)OCTANE-3,5'-(1,3)OXATHIOLANE), 2'-METHYL-;cevimelinum;D07667;cis-2-Methyl-1'-azaspiro[[1,3]oxathiolane-5,3'-bicyclo[2.2.2]octane];107233-08-9;UNII-K9V0CDQ56E;(2'R,3R)-2'-Methylspiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane];SCHEMBL188381;cevimelina;(2R,5'R)-5'-methyl-4-azaspiro[bicyclo[2.2.2]octane-2,2'-[1,4]oxathiolane]
SMILES: S1[C@]([H])(C([H])([H])[H])O[C@@]2(C1([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C2([H])C([H])([H])C1([H])[H]
Formula: C10H17NOs
M.Wt: 199.3131
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A potent M1-selective muscarinic agonist; decreases the K+-evoked [3H]ACh release from hippocampal synaptosomes and increases the K+-evoked [3H]DA release from striatal synaptosomes; attenuates cognitive dysfunctions in AF64A-treated rats with low toxicity.Other IndicationApproved
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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