Laduviglusib trihydrochloride| CAS 1782235-14-6

Cas No.:	1782235-14-6
Chemical Name:	Laduviglusib trihydrochloride
Synonyms:	CHIR-99021 (trihydrochloride);CHIR99021 trihydrochloride;CT99021 trihydrochloride;CT-99021 trihydrochloride;CHIR 99021 trihydrochloride;LMF6N91874;6-((2-((4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile trichloride;6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile;trihydrochloride;Laduviglusib trihydrochloride;B;CHIR-99021 trihydrochloride;6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile trihydrochloride;6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethy l]amino]-3-pyridinecarbonitrile trihydrochloride;CT99021 trihydrochloride;Laduviglusib trihydrochloride;AKOS024458433;HY-10182B;6-[(2-{[4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino}ethyl)amino]pyridine-3-carbonitrile trihydrochloride;1782235-14-6;E77136;Laduviglusib (trihydrochloride);UNII-LMF6N91874;6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitriletrihydrochloride;DA-51834;CT99021 trihydrochloride;CHIR-99021 3HCl; GSK 3 inhibitor XVI; GSK 3IXV;HB1262;C22H18Cl2N8.3HCl;CHIR-911 trihydrochloride;AKOS032945109;BCP26069;BS-51937;CS-5970;3-Pyridinecarbonitrile, 6-((2-((4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl)amino)ethyl)amino)-, hydrochloride (1:3)
SMILES:	ClC1C([H])=C(C([H])=C([H])C=1C1C(=C([H])N=C(N=1)N([H])C([H])([H])C([H])([H])N([H])C1C([H])=C([H])C(C#N)=C([H])N=1)C1=NC([H])=C(C([H])([H])[H])N1[H])Cl.Cl[H].Cl[H].Cl[H]
Formula:	C₂₂H₂₁Cl₅N₈
M.Wt:	574.7207
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent, specific GSK-3 inhibitor with IC50 of 5 nM and 10 nM for GSK3β and GSK3α, respectively; mimics Wnt signaling in preadipocytes, stabilizes free cytosolic beta-catenin and inhibits adipogenesis by blocking induction of C/EBPα and PPARγ; potentiates insulin activation of glucose transport and utilization in vitro and in vivo; also widely used for stem cell differentiation and naive stem cell generation.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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