Quizartinib hydrochloride| CAS 1132827-21-4

Cas No.:	1132827-21-4
Chemical Name:	N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea dihydrochloride
Synonyms:	AC220; AC 220; AC-220; AC010220; AC-010220; AC 010220; AC010220.2HCl; Quizartinib; Quizartinib HCl; Quizartinib dihydrochloride..
SMILES:	Cl.Cl.O=C(NC1=CC=C(C=C1)C2=CN3C(=N2)SC4=C3C=CC(OCCN5CCOCC5)=C4)NC6C=C(ON=6)C(C)(C)C
Formula:	C₂₉H₃₄Cl₂N₆O₄S
M.Wt:	633.589
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Quizartinib (AC220) is a potent, selective, second-generation FLT3 inhibitor with Kd of 1.6 nM, inhibits Wt FLT3 and FLT3-ITD autophosphorylation in MV4-11cell with IC50 of 4.2 and 1.1 nM, respectively; displays excellent kinase selectivity in a KinomeScan panel of 402 kinase binding assays, also potently inhibits PDGFRA, PDGFRB and RET; inhibits MV4-11 cell proliferarion with IC50 of 0.56 nM, demonstrates antitumor efficacy in the MV4-11 tumor xenograft model.Blood CancerPhase 3 Clinical

MSDS

COA

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2018-0101

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