PI-103 hydrochloride |CAS 371935-79-4|DC Chemicals

Cas No.:	371935-79-4
Chemical Name:	PI-103 Hydrochloride
Synonyms:	PI103 hydrochloride;PubChem22442;AGN-PC-0155FQ;CHEMBL538346;ABP000093;HY-10115A;CS-0760;3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol,hydrochloride;PI-103 (Hydrochloride);PI103 Free base;3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol;hydrochloride;PI 103 HYDROCHLORIDE;3-[4-(4-Morpholinylpyrido[3',2':4,5]f uro[3,2-d]pyrimidin-2-yl]phenol hydrochloride;C19H16N4O3.ClH;C19H16N4O3.HCl;3971AH;LT0082;SB10966;3-(4-Morpholinopyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl)phenol hydrochloride;PI 103 hydrochloride;PI103 hydrochloride;3-[4-(4-morpholinyl)p;PI-103 Hydrochloride
SMILES:	Cl.O1CCN(C2=C3C(C4=CC=CN=C4O3)=NC(C3C=CC=C(C=3)O)=N2)CC1
Formula:	C₁₉H₁₇ClN₄O₃
M.Wt:	384.816282987595
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent, dual class I PI3K/mTOR inhibitor with IC50 of 2/3/3/15/ for p110α/β/δ/γ, respectively; also inhibits TORC1 (>80% inhibition at 0.5 uM) and DNA-PK (IC50=14 nM), 15- to 20-fold less activity against class II PI3K C2β (IC50=43 nM), >1,300-fold selectivity over the class III PI3K Vsp34; potently inhibits proliferation and invasion of a wide variety of human cancer cells in vitro; shows activity in cancer xenograft models.

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2018-0101

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