Midodrine| CAS 42794-76-3

Cas No.:	42794-76-3
Chemical Name:	2-amino-N-2-(2,5-dimethoxyphenyl)-2-hydroxyethylacetamide
Synonyms:	MIDODRINE;Acetamide, 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]- (9CI);2-Amino-N-(2,5-dimethoxy-β-hydroxyphenethyl)acetamide;(±)-Midodrine;2-amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)acetamide;Acetamide,2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-;2-amino-N-2-(2,5-dimethoxyphenyl)-2-hydroxyethylacetamide;C07890;NCGC00178238-02;(+/-)-2-amino-n-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide;42794-76-3 (free base);RS)-N'-(beta-Hydroxy-2,5-dimethoxy-phenethyl)glycinamid;HY-12749;EN300-25893675;1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol;EINECS (255-945-3);N-{2-[2,5-bis(methyloxy)phenyl]-2-hydroxyethyl}glycinamide;MIDODRINE [HSDB];PTKSEFOSCHHMPD-UHFFFAOYSA-N;NCGC00178238-01;CHEMBL1201212;CS-4688;HSDB 7854;midodrine;St 1085;Acetamide, 2-amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)-;BRD-A79981887-003-05-7;(+-)-2-amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide;KBio3_002650;DTXSID0023321;CHEBI:6933;MIDODRINE [WHO-DD];Midodrin;MIDODRINE [INN];KBioGR_000763;Midodrina [INN-Spanish];2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethylacetamide;Spectrum_001641;ACETAMIDE, 2-AMINO-N-(2-(2,5-DIMETHOXYPHENYL)-2-HYDROXYETHYL)-, (+/-)-;Prestwick0_000191;Midodrina (INN-Spanish);SBI-0051934.P002;AB00053715_08;BSPBio_000141;2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]ethanimidic acid;2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide;DL-N1-(beta-Hydroxy-2,5-dimethoxyphenethyl)glycinamid;EINECS 255-945-3;2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethyl)acetamide;BPBio1_000157;SPBio_002062;KBio2_007257;UNII-6YE7PBM15H;Midodrina;Midodrinum (INN-Latin);Midodrinum;2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethyl)acetamid;BRD-A79981887-003-09-9;KBio1_000955;DB00211;DivK1c_000955;Spectrum3_001585;AKOS015967099;Spectrum5_000962;IDI1_000955;NS00008914;DTXCID903321;KBio2_004689;Q415051;SCHEMBL20996761;FT-0740719;KBio2_002121;rac-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]glycinamide;Midodrine [INN:BAN];Midodrinum [INN-Latin];133163-28-7;BSPBio_003150;A913477;(RS)-N'-(beta-Hydroxy-2,5-dimethoxy-phenethyl)glycinamid;ST-1085;C01CA17;GTPL7240;SCHEMBL131436;MIDODRINE [MI];s5735;MIDODRINE [VANDF];D08220;Midodrine (INN);HMS3886M20;rac-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)glycinamide;ProAmatine;KBioSS_002121;AB00053715;Midodrine free base;Prestwick3_000191;Prestwick1_000191;Spectrum2_001545;42794-76-3;NINDS_000955;Spectrum4_000192;(+/-)-2-AMINO-N-(.BETA.-HYDROXY-2,5-DIMETHOXYPHENETHYL)ACETAMIDE;6YE7PBM15H;Prestwick2_000191;SPBio_001390;(±)-Midodrin
SMILES:	O=C(NCC(C1=CC(OC)=CC=C1OC)O)CN
Formula:	C₁₂H₁₈N₂O₄
M.Wt:	254.28232
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Midodrine is a selective α1-adrenoceptor agonist that acts as a vasopressor/antihypotensive agent for the treatment of dysautonomia and orthostatic hypotension; activates the alpha-adrenergic receptors of the arteriolar and venous vasculature, producing an increase in vascular tone and elevation of blood pressure; does not stimulate cardiac beta-adrenergic receptors, and diffuses poorly across the blood-brain barrier.HypertensionApproved

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC33635	DODAP	DODAP, also known as 1,2-Dioleoyl-3-dimethylammonium-propane, is a cationic lipid. It has been used as a component in liposomes that can be used to encapsulate siRNA, immunostimulatory oligodeoxynucleotides, antisense oligonucleotides, or chemotherapeutic agents for in vitro and in vivo delivery.
DC31074	Isopropyl myristate	Isopropyl myristate is the ester of isopropyl alcohol and myristic acid.
DC74557	PREX-in1	PREX-in1 is a specific small-molecule inhibitor of P-Rex1 and P-Rex2 Rac-GEF activity with IC50 of 4.5 uM (P-Rex1 DHPH Rac-GEF activity) in liposome-based GEF assay, inhibits P-Rex1 and P-Rex2 through their catalytic DH domain.
DC74555	GYS32661	GYS32661 (GYS 32661) is a potent Rac inhibitor capable of inhibiting both Rac1 and Rac1b, inhibited activated Rac1 with IC50 of 1.18 uM in in vitro pull-down assays.
DC74539	L557-0155	L557-0155 is a small molecule inhibitor of VSIG-8, prevents VSIG-8 binding to VISTA, promotes cytokine production and cell proliferation in PBMCs and suppresses melanoma growth.
DC74528	K284	K284 is a selective small molecule inhibitor of chitinase 3 like1 (CHI3L1) with strong binding affinity (Kd=-9.7 kcal·mol-1), inhibits lung metastasis by blocking IL-13Rα2-mediated JNK-AP-1 signals.
DC74225	YB-537	YB-537 (YB537) is a potent, highly specific quinone reductase 2 (QR2) inhibitor with IC50 of 3 nM, shows no activity against QR1 (IC50>10 uM).
DC74218	UT-59	UT-59 is a specific inhibitor of cholesterol-sensing membrane protein Scap, binds to Scap's cholesterol-binding site, blocks SREBP activation and inhibits lipid synthesis.
DC74205	Tryptolinamide	Tryptolinamide (TLAM) is a small-molecule compound that activates mitochondrial respiration in cybrids generated from patient-derived mitochondria and fibroblasts from patient-derived iPSCs, inhibits phosphofructokinase-1 (PFK1) with an ATP-uncompetitive
DC74198	TMX-4102	TMX-4102 (TMX4102) is a highly potent, selective PIP4K2C binder with KD of 0.45 nM, shows no affinity for PIP4K2B and PIP4K2A (KD>10 uM).