DG-172 dihydrochloride| CAS 1361504-77-9

Cas No.:	1361504-77-9
Chemical Name:	DG172 dihydrochloride
Synonyms:	DG 172 dihydrochloride;DG172 (dihydrochloride);DG-172 dihydrochloride;DG172 2HCl;DG172 dihydrochloride;(Z)-2-(2-bromophenyl)-3-(4-(4-methylpiperazin-1-yl)phenyl)acrylonitrile dihydrochloride;(?Z)-2-Bromo-?-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitrile dihydrochloride
SMILES:	BrC1=C([H])C([H])=C([H])C([H])=C1/C(/C#N)=C(\[H])/C1C([H])=C([H])C(=C([H])C=1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H].Cl[H].Cl[H]
Formula:	C₂₀H₂₂BrCl₂N₃
M.Wt:	455.2188
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

DG-172 is a novel PPARβ/δ-selective ligand showing high binding affinity (IC50= 27 nM) and potent inverse agonistic properties; inhibits agonist-induced activity of PPARβ/δ, enhances transcriptional corepressor recruitment; down-regulates transcription of the PPARβ/δ target gene Angptl4 in mouse myoblasts (IC50= 9.5 nM); orally bioactive.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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