KX2-391 dihydrochloride| CAS 1038395-65-1

Cas No.:	1038395-65-1
Chemical Name:	5-[4-[2-(4-Morpholinyl)ethoxy]phenyl]-N-(phenylmethyl)-2-pyridineacetamide hydrochloride
Synonyms:	5-[4-[2-(4-Morpholinyl)ethoxy]phenyl]-N-(phenylmethyl)-2-pyridineacetamide hydrochloride;KX2-391;KX2-391 (dihydrochloride);N-benzyl-2-[5-[4-(2-morpholin-4-ylethoxy)phenyl]pyridin-2-yl]acetamide,dihydrochloride;CS-0455;KX2-391 2HCl;KX2-391 dihydrochloride;KW-2449 HCl;(E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone hydrochloride;5-[4-[2-(4-Morpholinyl)ethoxy]phenyl]-N-(phenylmethyl)-2-pyridineacetamide hydrochlorideKX2-391 (dihydrochloride);Tirbanibulin dihydrochloride
SMILES:	O=C(CC1=NC=C(C2=CC=C(OCCN3CCOCC3)C=C2)C=C1)NCC4=CC=CC=C4.Cl.Cl
Formula:	C₂₆H₂₉N₃O₃^.₂[HCl]
M.Wt:	504.44864
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A highly selective, non-ATP competitive substrate-pocket-directed Src/pretubulin inhibitor; inhibits c-Src kinase with GI50s of 1.34 uM and 2.30 μM in NIH3T3/c-Src527F and SYF/c-Src527F cells, respectively; causes microtubule disruption in tumor cells; orally active.Solid TumorsPhase 2 Clinical

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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