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(R)-(-)-Ibuprofen

  Cat. No.:  DC24168   Featured
Chemical Structure
51146-57-7
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More than 5000 active chemicals with high quality for research!
Field of application
An enantiomer of Ibuprofen that is generally not considered a COX inhibitor and is instead thought to be involved in pathways of lipid metabolism as it is incorporated into triglycerides along with fatty acids.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 51146-57-7
Chemical Name: (R)-(-)-Ibuprofen
Synonyms: Benzeneacetic acid, a-methyl-4-(2-methylpropyl)-, (aR)-;(R)-(-)-Ibuprofen;(alphaR)-alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid;L-Ibuprofen;R-(-)-p-Isobutylhydratropic acid;R(-)-ibuprofen;CHEBI:47835;alphaR-Sethyl-4-(2-methylpropyl)benzeneacetic acid;(2R)-2-(4-isobutylphenyl)-propanoic acid;(2R)-2-(4-isobutylphenyl)propanoic acid;(-)-Ibuprofen;R-Ibuprofen;(R)-Ibuprofen;​(R)-Ibuprofen​
SMILES: C[C@@H](C(=O)O)C1C=CC(CC(C)C)=CC=1
Formula: C13H18O2
M.Wt: 206.280824184418
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.
Target: NF-κB
In Vitro: (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, with no inhibitory effect on COX, but is involved in pathways of lipid metabolism and is incorporated into triglycerides along with endogenous fatty acids[1]. (R)-(-)-Ibuprofen (1 μM) significantly reduces NF-κB activation and completely prevents NF-κB induction at 10 μM. (R)-(-)-Ibuprofen inhibits NF-κB luciferase activity with an IC50 of 121.8 μM, weaker than that of S(+)-ibuprofen (IC50, 61.7 μM). Furthermore, (R)-(-)-Ibuprofen (10 mM) has no effect on HSF[2].
References: [1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14. [2]. Scheuren N, et al. Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen. Br J Pharmacol. 1998 Feb;123(4):645-52.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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