Cyclophosphamide hydrate| CAS 6055-19-2

Cas No.:	6055-19-2
Chemical Name:	2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate
Synonyms:	Ciclofosfamida; Ciclofosfamide; Cyclophosphamide monohydrate.
SMILES:	O.ClCCN(CCCl)P1(=O)NCCCO1
Formula:	C₇H₁₅Cl₂N₂O₂P
M.Wt:	279.10124
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.

In Vitro:

Cyclophosphamide induces outer membrane blebbing, leads to DNA fragmentation, as revealed by TUNEL staining of free 3'-OH DNA ends, and induces cleavage of the caspase 3 and caspase 7 substrate PARP in 9L/P450 cells. Bcl-2 expression fully blocks the activation of both initiator caspases as well as the effector caspase 3 in cells treated with activated Cyclophosphamide. Bcl-2 inhibits the cytotoxic effects but not the cytostatic effects of activated Cyclophosphamide[1]. Cyclophosphamide inhibits the AChE reversibly with an IC50 of 511 μM[2]. Carbon tetrachloride does not affect the direct cytotoxicity of cyclophosphamide or 4-hydroxycyclophosphamide to cells in culture[3].

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101
2018-0101

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